1gyb

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<StructureSection load='1gyb' size='340' side='right'caption='[[1gyb]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='1gyb' size='340' side='right'caption='[[1gyb]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1gyb]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GYB OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1GYB FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1gyb]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GYB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GYB FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1gy5|1gy5]], [[1gy6|1gy6]], [[1gy7|1gy7]]</td></tr>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1gy5|1gy5]], [[1gy6|1gy6]], [[1gy7|1gy7]]</div></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1gyb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gyb OCA], [http://pdbe.org/1gyb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gyb RCSB], [http://www.ebi.ac.uk/pdbsum/1gyb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1gyb ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gyb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gyb OCA], [https://pdbe.org/1gyb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gyb RCSB], [https://www.ebi.ac.uk/pdbsum/1gyb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gyb ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NTF2_YEAST NTF2_YEAST]] Facilitates protein transport into the nucleus. Interacts with various nucleoporins and with Ran-GDP. Could be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import. In vitro, the NTF2-Ran-GDP association, in the presence of GTP, triggers dissociation of the karyopherin alpha-beta complex, allowing nuclear translocation of karyopherin alpha and the NLS substrate.
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[[https://www.uniprot.org/uniprot/NTF2_YEAST NTF2_YEAST]] Facilitates protein transport into the nucleus. Interacts with various nucleoporins and with Ran-GDP. Could be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import. In vitro, the NTF2-Ran-GDP association, in the presence of GTP, triggers dissociation of the karyopherin alpha-beta complex, allowing nuclear translocation of karyopherin alpha and the NLS substrate.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]

Revision as of 10:50, 6 April 2022

N77Y point mutant of yNTF2 bound to FxFG nucleoporin repeat

PDB ID 1gyb

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