1byj

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[[Image:1byj.jpg|left|200px]]
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{{Seed}}
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[[Image:1byj.png|left|200px]]
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{{STRUCTURE_1byj| PDB=1byj | SCENE= }}
{{STRUCTURE_1byj| PDB=1byj | SCENE= }}
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'''GENTAMICIN C1A A-SITE COMPLEX'''
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===GENTAMICIN C1A A-SITE COMPLEX===
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==Overview==
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Aminoglycoside antibiotics that bind to the ribosomal A site cause misreading of the genetic code and inhibit translocation. The clinically important aminoglycoside, gentamicin C, is a mixture of three components. Binding of each gentamicin component to the ribosome and to a model RNA oligonucleotide was studied biochemically and the structure of the RNA complexed to gentamicin C1a was solved using magnetic resonance nuclear spectroscopy. Gentamicin C1a binds in the major groove of the RNA. Rings I and II of gentamicin direct specific RNA-drug interactions. Ring III of gentamicin, which distinguishes this subclass of aminoglycosides, also directs specific RNA interactions with conserved base pairs. The structure leads to a general model for specific ribosome recognition by aminoglycoside antibiotics and a possible mechanism for translational inhibition and miscoding. This study provides a structural rationale for chemical synthesis of novel aminoglycosides.
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The line below this paragraph, {{ABSTRACT_PUBMED_9822590}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9822590 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9822590}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BYJ OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BYJ OCA].
==Reference==
==Reference==
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[[Category: Puglisi, J D.]]
[[Category: Puglisi, J D.]]
[[Category: Yoshizawa, S.]]
[[Category: Yoshizawa, S.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:07:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:57:13 2008''

Revision as of 16:57, 30 June 2008

Image:1byj.png

Template:STRUCTURE 1byj

GENTAMICIN C1A A-SITE COMPLEX

Template:ABSTRACT PUBMED 9822590

About this Structure

Full experimental information is available from OCA.

Reference

Structural origins of gentamicin antibiotic action., Yoshizawa S, Fourmy D, Puglisi JD, EMBO J. 1998 Nov 16;17(22):6437-48. PMID:9822590

Page seeded by OCA on Mon Jun 30 19:57:13 2008

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