5k9r

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Current revision (10:43, 27 September 2023) (edit) (undo)
 
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<StructureSection load='5k9r' size='340' side='right'caption='[[5k9r]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='5k9r' size='340' side='right'caption='[[5k9r]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5k9r]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K9R OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5K9R FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5k9r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K9R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5K9R FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6RC:4-[5-[1-(2-METHOXYETHYL)PYRAZOL-4-YL]-2-(QUINOLIN-2-YLOXYMETHYL)IMIDAZO[1,2-A]PYRAZIN-8-YL]MORPHOLINE'>6RC</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PDE10A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6RC:4-[5-[1-(2-METHOXYETHYL)PYRAZOL-4-YL]-2-(QUINOLIN-2-YLOXYMETHYL)IMIDAZO[1,2-A]PYRAZIN-8-YL]MORPHOLINE'>6RC</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5k9r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k9r OCA], [http://pdbe.org/5k9r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k9r RCSB], [http://www.ebi.ac.uk/pdbsum/5k9r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k9r ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5k9r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k9r OCA], [https://pdbe.org/5k9r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5k9r RCSB], [https://www.ebi.ac.uk/pdbsum/5k9r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5k9r ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
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[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Gibbs, A G]]
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[[Category: Gibbs AG]]
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[[Category: Schubert, C]]
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[[Category: Schubert C]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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Current revision

PDE10a with imidazopyrazine inhibitor

PDB ID 5k9r

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OCA

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