Cell death protein
From Proteopedia
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'''Cell death proteins''' or '''Programmed cell death protein''' or '''CD279''' (CED) are involved in the process of cellular apoptosis. '''CED-1''' is a T cell regulator. CED-1 is expressed on the surface of T cells, B cells and macrophages. It is a membrane protein and acts in suppressing the immune system during pregnancy, tissue allografts, autoimmune diseases and hepatitis. CED-1 has 2 ligands: CED-L1 and CED-L2. Formation of CED-1/CED-L1 complex reduces T cell proliferation at the lymph nodes. <ref>PMID:26602187</ref> For details on '''CED-4''' see [[CED-4 Apoptosome]]. <scene name='50/507728/Cv/2'>Programmed cell death protein 1 and programmed cell death 1 ligand 1 complex with glycerol</scene> ([[3bik]]).<ref>PMID:18287011</ref>. For details on '''CED-8''' see [[Apoptosis-inducing factor]]. | '''Cell death proteins''' or '''Programmed cell death protein''' or '''CD279''' (CED) are involved in the process of cellular apoptosis. '''CED-1''' is a T cell regulator. CED-1 is expressed on the surface of T cells, B cells and macrophages. It is a membrane protein and acts in suppressing the immune system during pregnancy, tissue allografts, autoimmune diseases and hepatitis. CED-1 has 2 ligands: CED-L1 and CED-L2. Formation of CED-1/CED-L1 complex reduces T cell proliferation at the lymph nodes. <ref>PMID:26602187</ref> For details on '''CED-4''' see [[CED-4 Apoptosome]]. <scene name='50/507728/Cv/2'>Programmed cell death protein 1 and programmed cell death 1 ligand 1 complex with glycerol</scene> ([[3bik]]).<ref>PMID:18287011</ref>. For details on '''CED-8''' see [[Apoptosis-inducing factor]]. | ||
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| + | [[Cell death protein 3D structures]] | ||
</StructureSection> | </StructureSection> | ||
==3D structures of cell death protein== | ==3D structures of cell death protein== | ||
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*CED-1 | *CED-1 | ||
| - | **[[3rrq]] - hCED-1 extracellular domain (mutant) - human<br /> | + | **[[3rrq]], [[6umu]], [[6umv]] - hCED-1 extracellular domain (mutant) - human<br /> |
**[[2m2d]] - hCED-1 extracellular domain - NMR<br /> | **[[2m2d]] - hCED-1 extracellular domain - NMR<br /> | ||
| - | **[[4zqk]], [[5ius]] - hCED-1 extracellular domain (mutant) + hCED-1 ligand<br /> | ||
**[[5wt9]], [[5jxe]], [[5b8c]] - hCED-1 extracellular domain + antibody<br /> | **[[5wt9]], [[5jxe]], [[5b8c]] - hCED-1 extracellular domain + antibody<br /> | ||
| - | **[[5ggs]], [[5ggr]] - hCED-1 extracellular domain (mutant) + antibody<br /> | + | **[[5ggs]], [[5ggr]], [[6hig]], [[6j14]], [[6j15]], [[6jbt]], [[6jjp]], [[6k0y]], [[7bxa]] - hCED-1 extracellular domain (mutant) + antibody<br /> |
| + | **[[4zqk]], [[5ius]] - hCED-1 extracellular domain (mutant) + hCED-L1<br /> | ||
| + | **[[6umt]] - hCED-1 extracellular domain (mutant) + hCED-L2 extracellular domain<br /> | ||
**[[1npu]] – mCED-1 extracellular domain (mutant) - mouse<br /> | **[[1npu]] – mCED-1 extracellular domain (mutant) - mouse<br /> | ||
**[[3bik]] - mCED-1 extracellular domain (mutant) + hCED-L1 extracellular domain<br /> | **[[3bik]] - mCED-1 extracellular domain (mutant) + hCED-L1 extracellular domain<br /> | ||
Revision as of 07:11, 2 July 2020
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3D structures of cell death protein
Updated on 02-July-2020
References
- ↑ Zak KM, Kitel R, Przetocka S, Golik P, Guzik K, Musielak B, Domling A, Dubin G, Holak TA. Structure of the Complex of Human Programmed Death 1, PD-1, and Its Ligand PD-L1. Structure. 2015 Oct 22. pii: S0969-2126(15)00402-5. doi:, 10.1016/j.str.2015.09.010. PMID:26602187 doi:http://dx.doi.org/10.1016/j.str.2015.09.010
- ↑ Lin DY, Tanaka Y, Iwasaki M, Gittis AG, Su HP, Mikami B, Okazaki T, Honjo T, Minato N, Garboczi DN. The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors. Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):3011-6. Epub 2008 Feb 14. PMID:18287011
