1bzy

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1bzy.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1bzy.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1bzy| PDB=1bzy | SCENE= }}
{{STRUCTURE_1bzy| PDB=1bzy | SCENE= }}
-
'''HUMAN HGPRTASE WITH TRANSITION STATE INHIBITOR'''
+
===HUMAN HGPRTASE WITH TRANSITION STATE INHIBITOR===
-
==Overview==
+
<!--
-
The structure of human HGPRT bound to the transition-state analog immucillinGP and Mg2+-pyrophosphate has been determined to 2.0 A resolution. ImmucillinGP was designed as a stable analog with the stereoelectronic features of the transition state. Bound inhibitor at the catalytic site indicates that the oxocarbenium ion of the transition state is stabilized by neighboring-group participation from MgPPi and O5'. A short hydrogen bond forms between Asp 137 and the purine ring analog. Two Mg2+ ions sandwich the pyrophosphate and contact both hydroxyls of the ribosyl analog. The transition-state analog is shielded from bulk solvent by a catalytic loop that moves approximately 25 A to cover the active site and becomes an ordered antiparallel beta-sheet.
+
The line below this paragraph, {{ABSTRACT_PUBMED_10360366}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 10360366 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_10360366}}
==About this Structure==
==About this Structure==
Line 39: Line 43:
[[Category: Pyrophosphate]]
[[Category: Pyrophosphate]]
[[Category: Transition state]]
[[Category: Transition state]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:10:06 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:01:00 2008''

Revision as of 17:01, 30 June 2008

Image:1bzy.png


PDB ID 1bzy

Drag the structure with the mouse to rotate
1bzy, resolution 2.00Å ()
Ligands: , ,
Activity: Hypoxanthine phosphoribosyltransferase, with EC number 2.4.2.8
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



HUMAN HGPRTASE WITH TRANSITION STATE INHIBITOR

Template:ABSTRACT PUBMED 10360366

About this Structure

1BZY is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The 2.0 A structure of human hypoxanthine-guanine phosphoribosyltransferase in complex with a transition-state analog inhibitor., Shi W, Li CM, Tyler PC, Furneaux RH, Grubmeyer C, Schramm VL, Almo SC, Nat Struct Biol. 1999 Jun;6(6):588-93. PMID:10360366

Page seeded by OCA on Mon Jun 30 20:01:00 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1bzy"
Personal tools