1c15

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1c15.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1c15.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1c15| PDB=1c15 | SCENE= }}
{{STRUCTURE_1c15| PDB=1c15 | SCENE= }}
-
'''SOLUTION STRUCTURE OF APAF-1 CARD'''
+
===SOLUTION STRUCTURE OF APAF-1 CARD===
-
==Overview==
+
<!--
-
Direct recruitment and activation of caspase-9 by Apaf-1 through the homophilic CARD/CARD (Caspase Recruitment Domain) interaction is critical for the activation of caspases downstream of mitochondrial damage in apoptosis. Here we report the solution structure of the Apaf-1 CARD domain and its surface of interaction with caspase-9 CARD. Apaf-1 CARD consists of six tightly packed amphipathic alpha-helices and is topologically similar to the RAIDD CARD, with the exception of a kink observed in the middle of the N-terminal helix. By using chemical shift perturbation data, the homophilic interaction was mapped to the acidic surface of Apaf-1 CARD centered around helices 2 and 3. Interestingly, a significant portion of the chemically perturbed residues are hydrophobic, indicating that in addition to the electrostatic interactions predicted previously, hydrophobic interaction is also an important driving force underlying the CARD/CARD interaction. On the basis of the identified functional residues of Apaf-1 CARD and the surface charge complementarity, we propose a model of CARD/CARD interaction between Apaf-1 and caspase-9.
+
The line below this paragraph, {{ABSTRACT_PUBMED_10500165}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 10500165 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_10500165}}
==About this Structure==
==About this Structure==
-
1C15 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C15 OCA].
+
1C15 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C15 OCA].
==Reference==
==Reference==
Line 34: Line 38:
[[Category: Homophilic interaction]]
[[Category: Homophilic interaction]]
[[Category: Programmed cell death]]
[[Category: Programmed cell death]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:12:28 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:03:57 2008''

Revision as of 17:03, 30 June 2008

Image:1c15.png

Template:STRUCTURE 1c15

SOLUTION STRUCTURE OF APAF-1 CARD

Template:ABSTRACT PUBMED 10500165

About this Structure

1C15 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of Apaf-1 CARD and its interaction with caspase-9 CARD: a structural basis for specific adaptor/caspase interaction., Zhou P, Chou J, Olea RS, Yuan J, Wagner G, Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11265-70. PMID:10500165

Page seeded by OCA on Mon Jun 30 20:03:57 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1c15"
Personal tools