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6vgt
From Proteopedia
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==Solution NMR structure of enterococcal cytolysin L (CylLL") produced by Enterococcus faecalis== | ==Solution NMR structure of enterococcal cytolysin L (CylLL") produced by Enterococcus faecalis== | ||
| - | <StructureSection load='6vgt' size='340' side='right'caption='[[6vgt]]' scene=''> | + | <StructureSection load='6vgt' size='340' side='right'caption='[[6vgt]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full | + | <table><tr><td colspan='2'>[[6vgt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"enterococcus_proteiformis"_thiercelin_and_jouhaud_1903 "enterococcus proteiformis" thiercelin and jouhaud 1903]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VGT OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6VGT FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6vgt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vgt OCA], [http://pdbe.org/6vgt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vgt RCSB], [http://www.ebi.ac.uk/pdbsum/6vgt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vgt ProSAT]</span></td></tr> | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DBU:(2Z)-2-AMINOBUT-2-ENOIC+ACID'>DBU</scene>, <scene name='pdbligand=DHA:2-AMINO-ACRYLIC+ACID'>DHA</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6vgt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vgt OCA], [http://pdbe.org/6vgt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vgt RCSB], [http://www.ebi.ac.uk/pdbsum/6vgt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vgt ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The enterococcal cytolysin is a two-component lantibiotic of unknown structure with hemolytic activity that is important for virulence. We prepared cytolysin by coexpression of each precursor peptide with the synthetase CylM in Escherichia coli and characterized its structure. Unexpectedly, cytolysin is to our knowledge the first example of a lantibiotic containing lanthionine and methyllanthionine structures with different stereochemistries in the same peptide. The stereochemistry is determined by the sequence of the substrate peptide. | ||
| + | |||
| + | The sequence of the enterococcal cytolysin imparts unusual lanthionine stereochemistry.,Tang W, van der Donk WA Nat Chem Biol. 2013 Mar;9(3):157-9. doi: 10.1038/nchembio.1162. Epub 2013 Jan 13. PMID:23314913<ref>PMID:23314913</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6vgt" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Cytolysin 3D structures|Cytolysin 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Enterococcus proteiformis thiercelin and jouhaud 1903]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Bobeica | + | [[Category: Bobeica, S C]] |
| - | [[Category: Tang W]] | + | [[Category: Donk, W A.van der]] |
| - | [[Category: Zhu L]] | + | [[Category: Tang, W]] |
| - | [[Category: | + | [[Category: Zhu, L]] |
| + | [[Category: Cyclic peptide]] | ||
| + | [[Category: Cytolysin]] | ||
| + | [[Category: Lanthipeptide]] | ||
| + | [[Category: Posttranslational modification]] | ||
| + | [[Category: Toxin]] | ||
Revision as of 09:54, 9 September 2020
Solution NMR structure of enterococcal cytolysin L (CylLL") produced by Enterococcus faecalis
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