1c3t

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[[Image:1c3t.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1c3t| PDB=1c3t | SCENE= }}
{{STRUCTURE_1c3t| PDB=1c3t | SCENE= }}
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'''ROTAMER STRAIN AS A DETERMINANT OF PROTEIN STRUCTURAL SPECIFICITY'''
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===ROTAMER STRAIN AS A DETERMINANT OF PROTEIN STRUCTURAL SPECIFICITY===
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==Overview==
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We present direct evidence for a change in protein structural specificity due to hydrophobic core packing. High resolution structural analysis of a designed core variant of ubiquitin reveals that the protein is in slow exchange between two conformations. Examination of side-chain rotamers indicates that this dynamic response and the lower stability of the protein are coupled to greater strain and mobility in the core. The results suggest that manipulating the level of side-chain strain may be one way of fine tuning the stability and specificity of proteins.
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(as it appears on PubMed at http://www.pubmed.gov), where 10631975 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10631975}}
==About this Structure==
==About this Structure==
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1C3T is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C3T OCA].
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1C3T is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C3T OCA].
==Reference==
==Reference==
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[[Category: Rotamer]]
[[Category: Rotamer]]
[[Category: Ubiquitin]]
[[Category: Ubiquitin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:17:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:10:24 2008''

Revision as of 17:10, 30 June 2008

Image:1c3t.png

Template:STRUCTURE 1c3t

ROTAMER STRAIN AS A DETERMINANT OF PROTEIN STRUCTURAL SPECIFICITY

Template:ABSTRACT PUBMED 10631975

About this Structure

1C3T is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Rotamer strain as a determinant of protein structural specificity., Lazar GA, Johnson EC, Desjarlais JR, Handel TM, Protein Sci. 1999 Dec;8(12):2598-610. PMID:10631975

Page seeded by OCA on Mon Jun 30 20:10:24 2008

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