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2x2a

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<StructureSection load='2x2a' size='340' side='right'caption='[[2x2a]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
<StructureSection load='2x2a' size='340' side='right'caption='[[2x2a]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2x2a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X2A OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2X2A FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2x2a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X2A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X2A FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1vbs|1vbs]], [[1oca|1oca]], [[1mf8|1mf8]], [[2cyh|2cyh]], [[1cwb|1cwb]], [[1vbt|1vbt]], [[1m9e|1m9e]], [[1cwl|1cwl]], [[1cwc|1cwc]], [[1cwo|1cwo]], [[1cwi|1cwi]], [[1rmh|1rmh]], [[1cwj|1cwj]], [[2rmb|2rmb]], [[1m9c|1m9c]], [[1cwa|1cwa]], [[1cwf|1cwf]], [[3cyh|3cyh]], [[1m9y|1m9y]], [[4cyh|4cyh]], [[1m9f|1m9f]], [[1cwh|1cwh]], [[1bck|1bck]], [[1w8v|1w8v]], [[1awr|1awr]], [[1nmk|1nmk]], [[1mik|1mik]], [[1awv|1awv]], [[1m9d|1m9d]], [[1awt|1awt]], [[1fgl|1fgl]], [[2cpl|2cpl]], [[1m9x|1m9x]], [[1cwk|1cwk]], [[1m63|1m63]], [[5cyh|5cyh]], [[1ak4|1ak4]], [[3cys|3cys]], [[1w8l|1w8l]], [[2alf|2alf]], [[1aws|1aws]], [[2x25|2x25]], [[1w8m|1w8m]], [[1awu|1awu]], [[2rma|2rma]], [[1cwm|1cwm]], [[1awq|1awq]], [[2x2d|2x2d]], [[2x2c|2x2c]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1vbs|1vbs]], [[1oca|1oca]], [[1mf8|1mf8]], [[2cyh|2cyh]], [[1cwb|1cwb]], [[1vbt|1vbt]], [[1m9e|1m9e]], [[1cwl|1cwl]], [[1cwc|1cwc]], [[1cwo|1cwo]], [[1cwi|1cwi]], [[1rmh|1rmh]], [[1cwj|1cwj]], [[2rmb|2rmb]], [[1m9c|1m9c]], [[1cwa|1cwa]], [[1cwf|1cwf]], [[3cyh|3cyh]], [[1m9y|1m9y]], [[4cyh|4cyh]], [[1m9f|1m9f]], [[1cwh|1cwh]], [[1bck|1bck]], [[1w8v|1w8v]], [[1awr|1awr]], [[1nmk|1nmk]], [[1mik|1mik]], [[1awv|1awv]], [[1m9d|1m9d]], [[1awt|1awt]], [[1fgl|1fgl]], [[2cpl|2cpl]], [[1m9x|1m9x]], [[1cwk|1cwk]], [[1m63|1m63]], [[5cyh|5cyh]], [[1ak4|1ak4]], [[3cys|3cys]], [[1w8l|1w8l]], [[2alf|2alf]], [[1aws|1aws]], [[2x25|2x25]], [[1w8m|1w8m]], [[1awu|1awu]], [[2rma|2rma]], [[1cwm|1cwm]], [[1awq|1awq]], [[2x2d|2x2d]], [[2x2c|2x2c]]</div></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2x2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x2a OCA], [http://pdbe.org/2x2a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x2a RCSB], [http://www.ebi.ac.uk/pdbsum/2x2a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x2a ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x2a OCA], [https://pdbe.org/2x2a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x2a RCSB], [https://www.ebi.ac.uk/pdbsum/2x2a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x2a ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PPIA_HUMAN PPIA_HUMAN]] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
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[[https://www.uniprot.org/uniprot/PPIA_HUMAN PPIA_HUMAN]] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]

Current revision

Free acetyl-CypA trigonal form

PDB ID 2x2a

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