1c4e

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{{STRUCTURE_1c4e| PDB=1c4e | SCENE= }}
{{STRUCTURE_1c4e| PDB=1c4e | SCENE= }}
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'''GURMARIN FROM GYMNEMA SYLVESTRE'''
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===GURMARIN FROM GYMNEMA SYLVESTRE===
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==Overview==
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Gurmarin is a 35-residue polypeptide from the Asclepiad vine Gymnema sylvestre. It has been utilised as a pharmacological tool in the study of sweet-taste transduction because of its ability to selectively inhibit the neural response to sweet tastants in rats. We have chemically synthesised and folded gurmarin and determined its three-dimensional solution structure to high resolution using two-dimensional NMR spectroscopy. Structure calculations utilised 612 interproton-distance, 19 dihedral-angle, and 18 hydrogen-bond restraints. The structure is well defined for residues 3-34, with backbone and heavy atom rms differences of 0.27 +/- 0.09 A and 0.73 +/- 0.09 A, respectively. Gurmarin adopts a compact structure containing an antiparallel beta-hairpin (residues 22-34), several well-defined beta-turns, and a cystine-knot motif commonly observed in toxic and inhibitory polypeptides. Despite striking structural homology with delta-atracotoxin, a spider neurotoxin known to slow the inactivation of voltage-gated Na+ channels, we show that gurmarin has no effect on a variety of voltage-sensitive channels.
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{{ABSTRACT_PUBMED_10491100}}
==About this Structure==
==About this Structure==
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1C4E is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gymnema_sylvestre Gymnema sylvestre]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2gur 2gur]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C4E OCA].
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1C4E is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gymnema_sylvestre Gymnema sylvestre]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2gur 2gur]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C4E OCA].
==Reference==
==Reference==
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[[Category: Sweet taste suppression]]
[[Category: Sweet taste suppression]]
[[Category: Sweet taste transduction]]
[[Category: Sweet taste transduction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:19:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:11:47 2008''

Revision as of 17:11, 30 June 2008

Image:1c4e.png

Template:STRUCTURE 1c4e

GURMARIN FROM GYMNEMA SYLVESTRE

Template:ABSTRACT PUBMED 10491100

About this Structure

1C4E is a Single protein structure of sequence from Gymnema sylvestre. This structure supersedes the now removed PDB entry 2gur. Full experimental information is available from OCA.

Reference

High-resolution solution structure of gurmarin, a sweet-taste-suppressing plant polypeptide., Fletcher JI, Dingley AJ, Smith R, Connor M, Christie MJ, King GF, Eur J Biochem. 1999 Sep;264(2):525-33. PMID:10491100

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