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5kj0

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Current revision (10:01, 27 September 2023) (edit) (undo)
 
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<StructureSection load='5kj0' size='340' side='right'caption='[[5kj0]], [[Resolution|resolution]] 1.51&Aring;' scene=''>
<StructureSection load='5kj0' size='340' side='right'caption='[[5kj0]], [[Resolution|resolution]] 1.51&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5kj0]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KJ0 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5KJ0 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5kj0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KJ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KJ0 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6TB:4-[[(7~{R})-8-cyclopentyl-7-ethyl-5-methyl-6-oxidanylidene-7~{H}-pteridin-2-yl]-methyl-amino]-3-methoxy-~{N}-(1-methylpiperidin-4-yl)benzamide'>6TB</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.51&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5kj0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kj0 OCA], [http://pdbe.org/5kj0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kj0 RCSB], [http://www.ebi.ac.uk/pdbsum/5kj0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kj0 ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6TB:4-[[(7~{R})-8-cyclopentyl-7-ethyl-5-methyl-6-oxidanylidene-7~{H}-pteridin-2-yl]-methyl-amino]-3-methoxy-~{N}-(1-methylpiperidin-4-yl)benzamide'>6TB</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5kj0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kj0 OCA], [https://pdbe.org/5kj0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5kj0 RCSB], [https://www.ebi.ac.uk/pdbsum/5kj0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5kj0 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
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[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
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[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Ember, S W]]
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[[Category: Ember SW]]
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[[Category: Schonbrunn, E]]
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[[Category: Schonbrunn E]]
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[[Category: Zhu, J Y]]
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[[Category: Zhu J-Y]]
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[[Category: Bromodomain]]
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[[Category: Cap]]
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[[Category: Cell cycle]]
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[[Category: Hunk1]]
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[[Category: Inhibitor]]
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[[Category: Mcap]]
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[[Category: Mitotic chromosome associated protein]]
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[[Category: Protein binding-inhibitor complex]]
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[[Category: Transcription-inhibitor complex]]
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Current revision

CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH DB-1-264-2

PDB ID 5kj0

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