1c4z

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[[Image:1c4z.gif|left|200px]]
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{{STRUCTURE_1c4z| PDB=1c4z | SCENE= }}
{{STRUCTURE_1c4z| PDB=1c4z | SCENE= }}
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'''STRUCTURE OF E6AP: INSIGHTS INTO UBIQUITINATION PATHWAY'''
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===STRUCTURE OF E6AP: INSIGHTS INTO UBIQUITINATION PATHWAY===
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==Overview==
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The E6AP ubiquitin-protein ligase (E3) mediates the human papillomavirus-induced degradation of the p53 tumor suppressor in cervical cancer and is mutated in Angelman syndrome, a neurological disorder. The crystal structure of the catalytic hect domain of E6AP reveals a bilobal structure with a broad catalytic cleft at the junction of the two lobes. The cleft consists of conserved residues whose mutation interferes with ubiquitin-thioester bond formation and is the site of Angelman syndrome mutations. The crystal structure of the E6AP hect domain bound to the UbcH7 ubiquitin-conjugating enzyme (E2) reveals the determinants of E2-E3 specificity and provides insights into the transfer of ubiquitin from the E2 to the E3.
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==About this Structure==
==About this Structure==
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[[Category: E3 ubiquitin ligase]]
[[Category: E3 ubiquitin ligase]]
[[Category: Elongated shape]]
[[Category: Elongated shape]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:20:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:12:53 2008''

Revision as of 17:12, 30 June 2008

Image:1c4z.png

Template:STRUCTURE 1c4z

STRUCTURE OF E6AP: INSIGHTS INTO UBIQUITINATION PATHWAY

Template:ABSTRACT PUBMED 10558980

About this Structure

1C4Z is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade., Huang L, Kinnucan E, Wang G, Beaudenon S, Howley PM, Huibregtse JM, Pavletich NP, Science. 1999 Nov 12;286(5443):1321-6. PMID:10558980

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