1c5f

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{{STRUCTURE_1c5f| PDB=1c5f | SCENE= }}
{{STRUCTURE_1c5f| PDB=1c5f | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE CYCLOPHILIN-LIKE DOMAIN FROM BRUGIA MALAYI COMPLEXED WITH CYCLOSPORIN A'''
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===CRYSTAL STRUCTURE OF THE CYCLOPHILIN-LIKE DOMAIN FROM BRUGIA MALAYI COMPLEXED WITH CYCLOSPORIN A===
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==Overview==
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The resistance of the human parasite Brugia malayi to the antiparasitic activity of cyclosporin A (CsA) may arise from the presence of cyclophilins with relatively low affinity for the drug. The structure of the complex of B. malayi cyclophilin (BmCYP-1) and CsA, with eight independent copies in the asymmetric unit, has been determined at a resolution of 2.7 A. The low affinity of BmCYP-1 for CsA arises from incomplete preorganization of the binding site so that the formation of a hydrogen bond between His132 of BmCYP-1 and N-methylleucine 9 of CsA is associated with a shift in the backbone of approximately 1 A in this region.
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(as it appears on PubMed at http://www.pubmed.gov), where 10642184 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10642184}}
==About this Structure==
==About this Structure==
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[[Category: Peptidyl-prolyl cis-tran]]
[[Category: Peptidyl-prolyl cis-tran]]
[[Category: Peptidylprolyl isomerase]]
[[Category: Peptidylprolyl isomerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:21:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:14:07 2008''

Revision as of 17:14, 30 June 2008

Image:1c5f.png

Template:STRUCTURE 1c5f

CRYSTAL STRUCTURE OF THE CYCLOPHILIN-LIKE DOMAIN FROM BRUGIA MALAYI COMPLEXED WITH CYCLOSPORIN A

Template:ABSTRACT PUBMED 10642184

About this Structure

1C5F is a Single protein structure of sequence from Brugia malayi. This structure supersedes the now removed PDB entry 1qtl. Full crystallographic information is available from OCA.

Reference

Crystal structure of the complex of brugia malayi cyclophilin and cyclosporin A., Ellis PJ, Carlow CK, Ma D, Kuhn P, Biochemistry. 2000 Jan 25;39(3):592-8. PMID:10642184

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