1c6w

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{{STRUCTURE_1c6w| PDB=1c6w | SCENE= }}
{{STRUCTURE_1c6w| PDB=1c6w | SCENE= }}
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'''MAUROCALCIN FROM SCORPIO MAURUS'''
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===MAUROCALCIN FROM SCORPIO MAURUS===
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==Overview==
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We determined the structure in solution by (1)H two-dimensional NMR of Maurocalcine from the venom of Scorpio maurus. This toxin has been demonstrated to be a potent effector of ryanodyne-sensitive calcium channel from skeletal muscles. This is the first description of a scorpion toxin which folds following the Inhibitor Cystine Knot fold (ICK) already described for numerous toxic and inhibitory peptides, as well as for various protease inhibitors. Its three dimensional structure consists of a compact disulfide-bonded core from which emerge loops and the N-terminus. A double-stranded antiparallel beta-sheet comprises residues 20-23 and 30-33. A third extended strand (residues 9-11) is perpendicular to the beta-sheet. Maurocalcine structure mimics the activating segment of the dihydropyridine receptor II-III loop and is therefore potentially useful for dihydropyridine receptor/ryanodine receptor interaction studies. Proteins 2000;40:436-442.
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(as it appears on PubMed at http://www.pubmed.gov), where 10861934 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10861934}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C6W OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C6W OCA].
==Reference==
==Reference==
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[[Category: Ryanodine receptor effector]]
[[Category: Ryanodine receptor effector]]
[[Category: Scorpion toxin]]
[[Category: Scorpion toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:24:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:17:51 2008''

Revision as of 17:17, 30 June 2008

Image:1c6w.png

Template:STRUCTURE 1c6w

MAUROCALCIN FROM SCORPIO MAURUS

Template:ABSTRACT PUBMED 10861934

About this Structure

Full experimental information is available from OCA.

Reference

A new fold in the scorpion toxin family, associated with an activity on a ryanodine-sensitive calcium channel., Mosbah A, Kharrat R, Fajloun Z, Renisio JG, Blanc E, Sabatier JM, El Ayeb M, Darbon H, Proteins. 2000 Aug 15;40(3):436-42. PMID:10861934

Page seeded by OCA on Mon Jun 30 20:17:51 2008

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