6wk7
From Proteopedia
(Difference between revisions)
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==Crystal Structure Analysis of a poly(thymine) DNA duplex== | ==Crystal Structure Analysis of a poly(thymine) DNA duplex== | ||
| - | <StructureSection load='6wk7' size='340' side='right'caption='[[6wk7]]' scene=''> | + | <StructureSection load='6wk7' size='340' side='right'caption='[[6wk7]], [[Resolution|resolution]] 2.42Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WK7 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6WK7 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6wk7]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WK7 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6WK7 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6wk7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wk7 OCA], [http://pdbe.org/6wk7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6wk7 RCSB], [http://www.ebi.ac.uk/pdbsum/6wk7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6wk7 ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AX2:1,3,5-TRIAZINE-2,4,6-TRIAMINE'>AX2</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6wk7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wk7 OCA], [http://pdbe.org/6wk7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6wk7 RCSB], [http://www.ebi.ac.uk/pdbsum/6wk7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6wk7 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The diversity of DNA duplex structures is limited by a binary pair of hydrogen-bonded motifs. Here we show that poly(thymine) self-associates into antiparallel, right-handed duplexes in the presence of melamine, a small molecule that presents a triplicate set of the hydrogen-bonding face of adenine. X-ray crystallography shows that in the complex two poly(thymine) strands wrap around a helical column of melamine, which hydrogen bonds to thymine residues on two of its three faces. The mechanical strength of the thymine-melamine-thymine triplet surpasses that of adenine-thymine base pairs, which enables a sensitive detection of melamine at 3 pM. The poly(thymine)-melamine duplex is orthogonal to native DNA base pairing and can undergo strand displacement without the need for overhangs. Its incorporation into two-dimensional grids and hybrid DNA-small-molecule polymers highlights the poly(thymine)-melamine duplex as an additional tool for DNA nanotechnology. | ||
| + | |||
| + | A poly(thymine)-melamine duplex for the assembly of DNA nanomaterials.,Li Q, Zhao J, Liu L, Jonchhe S, Rizzuto FJ, Mandal S, He H, Wei S, Sleiman HF, Mao H, Mao C Nat Mater. 2020 Jul 13. pii: 10.1038/s41563-020-0728-2. doi:, 10.1038/s41563-020-0728-2. PMID:32661383<ref>PMID:32661383</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6wk7" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: He H]] | + | [[Category: He, H]] |
| - | [[Category: Jonchhe S]] | + | [[Category: Jonchhe, S]] |
| - | [[Category: Li Q]] | + | [[Category: Li, Q]] |
| - | [[Category: Liu L]] | + | [[Category: Liu, L]] |
| - | [[Category: Mandal S]] | + | [[Category: Mandal, S]] |
| - | [[Category: Mao C]] | + | [[Category: Mao, C]] |
| - | [[Category: Mao H]] | + | [[Category: Mao, H]] |
| - | [[Category: Rizzuto | + | [[Category: Rizzuto, F J]] |
| - | [[Category: Sleiman | + | [[Category: Sleiman, H F]] |
| - | [[Category: Wei S]] | + | [[Category: Wei, S]] |
| - | [[Category: Zhao J]] | + | [[Category: Zhao, J]] |
| + | [[Category: Dna]] | ||
| + | [[Category: Melamine-mediated]] | ||
Revision as of 07:09, 2 September 2020
Crystal Structure Analysis of a poly(thymine) DNA duplex
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Categories: Large Structures | He, H | Jonchhe, S | Li, Q | Liu, L | Mandal, S | Mao, C | Mao, H | Rizzuto, F J | Sleiman, H F | Wei, S | Zhao, J | Dna | Melamine-mediated
