2yly
From Proteopedia
(Difference between revisions)
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<StructureSection load='2yly' size='340' side='right'caption='[[2yly]], [[Resolution|resolution]] 3.20Å' scene=''> | <StructureSection load='2yly' size='340' side='right'caption='[[2yly]], [[Resolution|resolution]] 3.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2yly]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2yly]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YLY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YLY FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SU4:N-CYCLOPROPYL-4-OXIDANYL-N-[(2R)-2-OXIDANYL-2-PHENYL-PROPYL]BENZENESULFONAMIDE'>SU4</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SU4:N-CYCLOPROPYL-4-OXIDANYL-N-[(2R)-2-OXIDANYL-2-PHENYL-PROPYL]BENZENESULFONAMIDE'>SU4</scene></td></tr> | ||
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1yy4|1yy4]], [[1u3s|1u3s]], [[1x78|1x78]], [[1qkm|1qkm]], [[1u3r|1u3r]], [[1l2j|1l2j]], [[2fsz|2fsz]], [[1x7j|1x7j]], [[1x7b|1x7b]], [[1u9e|1u9e]], [[1x76|1x76]], [[1nde|1nde]], [[1yye|1yye]], [[2jj3|2jj3]], [[1u3q|1u3q]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1yy4|1yy4]], [[1u3s|1u3s]], [[1x78|1x78]], [[1qkm|1qkm]], [[1u3r|1u3r]], [[1l2j|1l2j]], [[2fsz|2fsz]], [[1x7j|1x7j]], [[1x7b|1x7b]], [[1u9e|1u9e]], [[1x76|1x76]], [[1nde|1nde]], [[1yye|1yye]], [[2jj3|2jj3]], [[1u3q|1u3q]]</div></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yly FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yly OCA], [https://pdbe.org/2yly PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yly RCSB], [https://www.ebi.ac.uk/pdbsum/2yly PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yly ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/ESR2_HUMAN ESR2_HUMAN]] Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual. |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Revision as of 12:32, 27 April 2022
Sulfonamides as selective Estrogen Receptor beta Agonists.
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Categories: Human | Large Structures | Armour, D | Barker, C | Bazin, R | Bess, K | Brown, A | Ellis, D | Favor, D | MacKenny, M | Phillips, C | Pullen, N | Roberts, L R | Stennett, A | Strand, L | Styles, M | Receptor
