Ferric hydroxamate uptake receptor

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== Function ==
== Function ==
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'''Ferric hydroxamate uptake receptor''' proteins FhuA, FhuB, FhuC and FhuD are involved in the uptake of the hydroxamate ferrichrome siderophore for use as an iron source<ref>PMID:17600077</ref>. For more details see [[FhuD]].
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'''Ferric hydroxamate uptake receptor''' or '''ferrichrome-binding periplasmic protein''' proteins FhuA, FhuB, FhuC and FhuD are involved in the uptake of the hydroxamate ferrichrome siderophore for use as an iron source<ref>PMID:17600077</ref>. For more details see [[FhuD]].
== Disease ==
== Disease ==
''Haemophilus parasuis'' uses Fhu to capture iron and is the cause of the Glasser disease in pigs.
''Haemophilus parasuis'' uses Fhu to capture iron and is the cause of the Glasser disease in pigs.

Revision as of 06:42, 26 July 2021

E. coli FhuA complex with ferrichrome and Fe+3 ion (orange) (PDB code 1by5).

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3D structures of Ferric hydroxamate uptake receptor

Updated on 26-July-2021

References

  1. Forman S, Nagiec MJ, Abney J, Perry RD, Fetherston JD. Analysis of the aerobactin and ferric hydroxamate uptake systems of Yersinia pestis. Microbiology. 2007 Jul;153(Pt 7):2332-41. PMID:17600077 doi:http://dx.doi.org/10.1099/mic.0.2006/004275-0
  2. Locher KP, Rees B, Koebnik R, Mitschler A, Moulinier L, Rosenbusch JP, Moras D. Transmembrane signaling across the ligand-gated FhuA receptor: crystal structures of free and ferrichrome-bound states reveal allosteric changes. Cell. 1998 Dec 11;95(6):771-8. PMID:9865695

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