1c8o

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[[Image:1c8o.gif|left|200px]]
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{{Seed}}
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[[Image:1c8o.png|left|200px]]
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{{STRUCTURE_1c8o| PDB=1c8o | SCENE= }}
{{STRUCTURE_1c8o| PDB=1c8o | SCENE= }}
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'''2.9 A STRUCTURE OF CLEAVED VIRAL SERPIN CRMA'''
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===2.9 A STRUCTURE OF CLEAVED VIRAL SERPIN CRMA===
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==Overview==
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CrmA is an unusual viral serpin that inhibits both cysteine and serine proteinases involved in the regulation of host inflammatory and apoptosis processes. It differs from other members of the serpin superfamily by having a reactive center loop that is one residue shorter, and by its apparent inability to form SDS-stable covalent complexes with cysteine proteinases. To obtain insight into the inhibitory mechanism of crmA, we determined the crystal structure of reactive center loop-cleaved crmA to 2.9 A resolution. The structure, which is the first of a viral serpin, suggests that crmA can inhibit cysteine proteinases by a mechanism analogous to that used by other serpins against serine proteinases. However, one striking difference from other serpins, which may be significant for in vivo function, is an additional highly charged antiparallel strand for b sheet A, whose sequence and length are unique to crmA.
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The line below this paragraph, {{ABSTRACT_PUBMED_10975564}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10975564 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10975564}}
==About this Structure==
==About this Structure==
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[[Category: Volz, K.]]
[[Category: Volz, K.]]
[[Category: Serpin fold]]
[[Category: Serpin fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:27:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:22:24 2008''

Revision as of 17:22, 30 June 2008

Image:1c8o.png

Template:STRUCTURE 1c8o

2.9 A STRUCTURE OF CLEAVED VIRAL SERPIN CRMA

Template:ABSTRACT PUBMED 10975564

About this Structure

1C8O is a Protein complex structure of sequences from Cowpox virus. Full crystallographic information is available from OCA.

Reference

Crystal structure of viral serpin crmA provides insights into its mechanism of cysteine proteinase inhibition., Simonovic M, Gettins PGW, Volz K, Protein Sci. 2000 Aug;9(8):1423-7. PMID:10975564

Page seeded by OCA on Mon Jun 30 20:22:24 2008

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