1c8u

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[[Image:1c8u.gif|left|200px]]
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{{Seed}}
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[[Image:1c8u.png|left|200px]]
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{{STRUCTURE_1c8u| PDB=1c8u | SCENE= }}
{{STRUCTURE_1c8u| PDB=1c8u | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE E.COLI THIOESTERASE II, A HOMOLOGUE OF THE HUMAN NEF-BINDING ENZYME'''
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===CRYSTAL STRUCTURE OF THE E.COLI THIOESTERASE II, A HOMOLOGUE OF THE HUMAN NEF-BINDING ENZYME===
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==Overview==
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Here we report the solution and refinement at 1.9 A resolution of the crystal structure of the Escherichia coli medium chain length acyl-CoA thioesterase II. This enzyme is a close homolog of the human protein that interacts with the product of the HIV-1 Nef gene, sharing 45% amino acid sequence identity with it. The structure of the E. coli thioesterase II reveals a new tertiary fold, a 'double hot dog', showing an internal repeat with a basic unit that is structurally similar to the recently described beta-hydroxydecanoyl thiol ester dehydrase. The catalytic site, inferred from the crystal structure and verified by site directed mutagenesis, involves novel chemistry and includes Asp 204, Gln 278 and Thr 228, which synergistically activate a nucleophilic water molecule.
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(as it appears on PubMed at http://www.pubmed.gov), where 10876240 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10876240}}
==About this Structure==
==About this Structure==
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[[Category: Li, J.]]
[[Category: Li, J.]]
[[Category: Internal repeat]]
[[Category: Internal repeat]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:28:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:22:50 2008''

Revision as of 17:22, 30 June 2008

Image:1c8u.png

Template:STRUCTURE 1c8u

CRYSTAL STRUCTURE OF THE E.COLI THIOESTERASE II, A HOMOLOGUE OF THE HUMAN NEF-BINDING ENZYME

Template:ABSTRACT PUBMED 10876240

About this Structure

1C8U is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of the Escherichia coli thioesterase II, a homolog of the human Nef binding enzyme., Li J, Derewenda U, Dauter Z, Smith S, Derewenda ZS, Nat Struct Biol. 2000 Jul;7(7):555-9. PMID:10876240

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