1c9h

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{{STRUCTURE_1c9h| PDB=1c9h | SCENE= }}
{{STRUCTURE_1c9h| PDB=1c9h | SCENE= }}
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'''CRYSTAL STRUCTURE OF FKBP12.6 IN COMPLEX WITH RAPAMYCIN'''
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===CRYSTAL STRUCTURE OF FKBP12.6 IN COMPLEX WITH RAPAMYCIN===
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==Overview==
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FKBP12.6 is a novel isoform of FKBP12, which selectively binds to the cardiac ryanodine receptor (RyR2). The crystal structure of FKBP12.6 in complex with rapamycin has now been determined at 2.0 A resolution. The structures of FKBP12.6 and FKBP12 are nearly identical, except for a displacement observed in the helical region of FKBP12.6 toward the hydrophobic pocket. This displacement was not predicted by homology modeling studies. Analyses of the residues that are likely to confer the RyR2-binding specificity are presented.
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(as it appears on PubMed at http://www.pubmed.gov), where 10713512 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10713512}}
==About this Structure==
==About this Structure==
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[[Category: Rapamycin]]
[[Category: Rapamycin]]
[[Category: Ryanodine receptor]]
[[Category: Ryanodine receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:29:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:24:25 2008''

Revision as of 17:24, 30 June 2008

Image:1c9h.png

Template:STRUCTURE 1c9h

CRYSTAL STRUCTURE OF FKBP12.6 IN COMPLEX WITH RAPAMYCIN

Template:ABSTRACT PUBMED 10713512

About this Structure

1C9H is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of FKBP12.6 in complex with rapamycin., Deivanayagam CC, Carson M, Thotakura A, Narayana SV, Chodavarapu RS, Acta Crystallogr D Biol Crystallogr. 2000 Mar;56(Pt 3):266-71. PMID:10713512

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