6zed
From Proteopedia
(Difference between revisions)
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==CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX with compound F1== | ==CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX with compound F1== | ||
| - | <StructureSection load='6zed' size='340' side='right'caption='[[6zed]]' scene=''> | + | <StructureSection load='6zed' size='340' side='right'caption='[[6zed]], [[Resolution|resolution]] 1.08Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZED OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[6zed]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZED OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZED FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=QGN:4,5-dimethyl-1~{H}-pyrazolo[3,4-c]pyridazin-3-amine'>QGN</scene></td></tr> |
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BRD4, HUNK1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zed FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zed OCA], [https://pdbe.org/6zed PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zed RCSB], [https://www.ebi.ac.uk/pdbsum/6zed PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zed ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Arrowsmith | + | [[Category: Arrowsmith, C H]] |
| - | [[Category: Barril X]] | + | [[Category: Barril, X]] |
| - | [[Category: Bountra C]] | + | [[Category: Bountra, C]] |
| - | [[Category: Edwards | + | [[Category: Delft, F von]] |
| - | [[Category: Filippakopoulos P]] | + | [[Category: Edwards, A M]] |
| - | [[Category: Krojer T]] | + | [[Category: Filippakopoulos, P]] |
| - | [[Category: Martinez-Cartro M]] | + | [[Category: Krojer, T]] |
| - | [[Category: Picaud S]] | + | [[Category: Martinez-Cartro, M]] |
| - | [[Category: | + | [[Category: Picaud, S]] |
| + | [[Category: Structural genomic]] | ||
| + | [[Category: Brd4]] | ||
| + | [[Category: Bromodomain-containing protein 4]] | ||
| + | [[Category: Bromodomain-containing protein 4 isoform long]] | ||
| + | [[Category: Cap]] | ||
| + | [[Category: Cell cycle]] | ||
| + | [[Category: Hunk1]] | ||
| + | [[Category: Mcap]] | ||
| + | [[Category: Mitotic chromosome associated protein]] | ||
| + | [[Category: Sgc]] | ||
Revision as of 10:17, 19 May 2021
CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX with compound F1
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Categories: Human | Large Structures | Arrowsmith, C H | Barril, X | Bountra, C | Delft, F von | Edwards, A M | Filippakopoulos, P | Krojer, T | Martinez-Cartro, M | Picaud, S | Structural genomic | Brd4 | Bromodomain-containing protein 4 | Bromodomain-containing protein 4 isoform long | Cap | Cell cycle | Hunk1 | Mcap | Mitotic chromosome associated protein | Sgc
