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6zp4
From Proteopedia
(Difference between revisions)
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| - | ==== | + | ==SARS-CoV-2 Nsp1 bound to a human 43S preinitiation ribosome complex - state 2== |
| - | <StructureSection load='6zp4' size='340' side='right'caption='[[6zp4]]' scene=''> | + | <StructureSection load='6zp4' size='340' side='right'caption='[[6zp4]], [[Resolution|resolution]] 2.90Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[6zp4]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZP4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZP4 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.9Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zp4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zp4 OCA], [https://pdbe.org/6zp4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zp4 RCSB], [https://www.ebi.ac.uk/pdbsum/6zp4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zp4 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RSSA_HUMAN RSSA_HUMAN] Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria.<ref>PMID:6300843</ref> <ref>PMID:16263087</ref> <ref>PMID:15516338</ref> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Nonstructural protein 3D structures|Nonstructural protein 3D structures]] | ||
| + | *[[Ribosome 3D structures|Ribosome 3D structures]] | ||
| + | *[[3D sructureseceptor for activated protein kinase C 1|3D sructureseceptor for activated protein kinase C 1]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Ameismeier M]] |
| + | [[Category: Becker T]] | ||
| + | [[Category: Beckmann R]] | ||
| + | [[Category: Berninghausen O]] | ||
| + | [[Category: Buschauer R]] | ||
| + | [[Category: Cheng J]] | ||
| + | [[Category: Denk T]] | ||
| + | [[Category: Kratzat H]] | ||
| + | [[Category: Mackens-Kiani T]] | ||
| + | [[Category: Thoms M]] | ||
Current revision
SARS-CoV-2 Nsp1 bound to a human 43S preinitiation ribosome complex - state 2
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Categories: Homo sapiens | Large Structures | Ameismeier M | Becker T | Beckmann R | Berninghausen O | Buschauer R | Cheng J | Denk T | Kratzat H | Mackens-Kiani T | Thoms M
