2aat

<table><tr><td colspan='2'>[[2aat]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AAT OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2AAT FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PMP:4-DEOXY-4-AMINOPYRIDOXAL-5-PHOSPHATE'>PMP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate_transaminase Aspartate transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.1 2.6.1.1] </span></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2aat FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aat OCA], [http://pdbe.org/2aat PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2aat RCSB], [http://www.ebi.ac.uk/pdbsum/2aat PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2aat ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

The three-dimensional structure of a mutant of the aspartate aminotransferase from Escherichia coli, in which the active-site lysine has been substituted by alanine (K258A), has been determined at 2.8-A resolution by X-ray diffraction. The mutant enzyme contains pyridoxamine phosphate as cofactor. The structure is compared to that of the mitochondrial aspartate aminotransferase. The most striking differences, aside from the absence of the lysine side chain, occur in the positions of the pyridoxamine group and of tryptophan 140.

2.8-A-resolution crystal structure of an active-site mutant of aspartate aminotransferase from Escherichia coli.,Smith DL, Almo SC, Toney MD, Ringe D Biochemistry. 1989 Oct 3;28(20):8161-7. PMID:2513875<ref>PMID:2513875</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 2aat" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Bacillus coli migula 1895]]

[[Category: Aspartate transaminase]]

[[Category: Almo, S C]]

[[Category: Ringe, D]]

[[Category: Smith, D]]

[[Category: Toney, M]]