6vwa
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==C-terminal regulatory domain of the chloride transporter KCC-1 from C. elegans== | ==C-terminal regulatory domain of the chloride transporter KCC-1 from C. elegans== | ||
| - | <StructureSection load='6vwa' size='340' side='right'caption='[[6vwa]]' scene=''> | + | <StructureSection load='6vwa' size='340' side='right'caption='[[6vwa]], [[Resolution|resolution]] 2.20Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VWA OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6VWA FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6vwa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Caeel Caeel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VWA OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6VWA FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6vwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vwa OCA], [http://pdbe.org/6vwa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vwa RCSB], [http://www.ebi.ac.uk/pdbsum/6vwa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vwa ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr> |
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">kcc-1, CELE_R13A1.2, R13A1.2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 CAEEL])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6vwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vwa OCA], [http://pdbe.org/6vwa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vwa RCSB], [http://www.ebi.ac.uk/pdbsum/6vwa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vwa ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Cation-chloride cotransporters (CCCs) regulate the movement of chloride across membranes, controlling physiological processes from cell volume maintenance to neuronal signaling. Human CCCs are clinical targets for existing diuretics and potentially additional indications. Here, we report the X-ray crystal structure of the soluble C-terminal regulatory domain of a eukaryotic potassium-chloride cotransporter, Caenorhabditis elegans KCC-1. We observe a core alpha/beta fold conserved among CCCs. Using structure-based sequence alignment, we analyze similarities and differences to the C-terminal domains of other CCC family members. We find that important regulatory motifs are in less-structured regions and residues important for dimerization are not widely conserved, suggesting that oligomerization and its effects may vary within the larger family. This snapshot of a eukaryotic KCC is a valuable starting point for the rational design of studies of cellular chloride regulation. | ||
| + | |||
| + | Structure of the Regulatory Cytosolic Domain of a Eukaryotic Potassium-Chloride Cotransporter.,Zimanyi CM, Guo M, Mahmood A, Hendrickson WA, Hirsh D, Cheung J Structure. 2020 Jul 10. pii: S0969-2126(20)30212-4. doi:, 10.1016/j.str.2020.06.009. PMID:32679039<ref>PMID:32679039</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6vwa" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Caeel]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Cheung J]] | + | [[Category: Cheung, J]] |
| - | [[Category: Zimanyi | + | [[Category: Zimanyi, C M]] |
| + | [[Category: Cation-chloride-cotransporter]] | ||
| + | [[Category: Cytosolic domain]] | ||
| + | [[Category: Slc transporter]] | ||
| + | [[Category: Transport protein]] | ||
Revision as of 09:54, 9 September 2020
C-terminal regulatory domain of the chloride transporter KCC-1 from C. elegans
| |||||||||||
