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2z5z

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Current revision (13:23, 1 November 2023) (edit) (undo)
 
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<StructureSection load='2z5z' size='340' side='right'caption='[[2z5z]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
<StructureSection load='2z5z' size='340' side='right'caption='[[2z5z]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2z5z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bubalus_bubalis Bubalus bubalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z5Z OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2Z5Z FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2z5z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bubalus_bubalis Bubalus bubalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z5Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z5Z FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=F:FLUORIDE+ION'>F</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=OSM:1-(OXIDOSULFANYL)METHANAMINE'>OSM</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=F:FLUORIDE+ION'>F</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=OSM:1-(OXIDOSULFANYL)METHANAMINE'>OSM</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2o86|2o86]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z5z OCA], [https://pdbe.org/2z5z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z5z RCSB], [https://www.ebi.ac.uk/pdbsum/2z5z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z5z ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peroxidase Peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.7 1.11.1.7] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2z5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z5z OCA], [http://pdbe.org/2z5z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2z5z RCSB], [http://www.ebi.ac.uk/pdbsum/2z5z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2z5z ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PERL_BUBBU PERL_BUBBU]] Antimicrobial agent which utilizes hydrogen peroxide and thiocyanate (SCN) to generate the antimicrobial substance hypothiocyanous acid (HOSCN). May protect the udder from infection and promote growth in newborn calves. Inhibits growth of the following bacterial species: E.coli, K.pneumoniae, P.aeruginosa, S.sonnei, S.saphrophyticus, S.epidermidis, and S.dysenteriae.<ref>PMID:12071645</ref>
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[https://www.uniprot.org/uniprot/PERL_BUBBU PERL_BUBBU] Antimicrobial agent which utilizes hydrogen peroxide and thiocyanate (SCN) to generate the antimicrobial substance hypothiocyanous acid (HOSCN). May protect the udder from infection and promote growth in newborn calves. Inhibits growth of the following bacterial species: E.coli, K.pneumoniae, P.aeruginosa, S.sonnei, S.saphrophyticus, S.epidermidis, and S.dysenteriae.<ref>PMID:12071645</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Bubalus bubalis]]
[[Category: Bubalus bubalis]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Peroxidase]]
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[[Category: Bhushan A]]
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[[Category: Bhushan, A]]
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[[Category: Jain R]]
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[[Category: Jain, R]]
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[[Category: Kaur P]]
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[[Category: Kaur, P]]
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[[Category: Sharma S]]
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[[Category: Sharma, S]]
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[[Category: Sheikh IA]]
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[[Category: Sheikh, I A]]
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[[Category: Singh N]]
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[[Category: Singh, N]]
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[[Category: Singh TP]]
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[[Category: Singh, T P]]
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[[Category: Srinivasan A]]
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[[Category: Srinivasan, A]]
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[[Category: Buffalo]]
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[[Category: Complex]]
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[[Category: Fluoride]]
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[[Category: Lactoperoxidase]]
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[[Category: Oxidoreductase]]
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Current revision

Crystal structure of the complex of buffalo Lactoperoxidase with fluoride ion at 3.5A resolution

PDB ID 2z5z

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