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2zbh

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Current revision (13:30, 1 November 2023) (edit) (undo)
 
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<StructureSection load='2zbh' size='340' side='right'caption='[[2zbh]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='2zbh' size='340' side='right'caption='[[2zbh]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2zbh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Daboia_russellii_pulchella Daboia russellii pulchella]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZBH OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2ZBH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2zbh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Daboia_russelii_pulchella Daboia russelii pulchella]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZBH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZBH FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BVL:(2E)-1-[2-HYDROXY-4-METHOXY-5-(3-METHYLBUT-2-EN-1-YL)PHENYL]-3-(4-HYDROXYPHENYL)PROP-2-EN-1-ONE'>BVL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2qvd|2qvd]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BVL:(2E)-1-[2-HYDROXY-4-METHOXY-5-(3-METHYLBUT-2-EN-1-YL)PHENYL]-3-(4-HYDROXYPHENYL)PROP-2-EN-1-ONE'>BVL</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zbh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zbh OCA], [https://pdbe.org/2zbh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zbh RCSB], [https://www.ebi.ac.uk/pdbsum/2zbh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zbh ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2zbh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zbh OCA], [http://pdbe.org/2zbh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zbh RCSB], [http://www.ebi.ac.uk/pdbsum/2zbh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2zbh ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PA2B8_DABRR PA2B8_DABRR]] Snake venom phospholipase A2 (PLA2) that shows weak neurotoxicity and medium anticoagulant effects by binding to factor Xa (F10) and inhibiting the prothrombinase activity (IC(50) is 130 nM) (PubMed:18062812). It also damages vital organs such as lung, liver and kidney, displays edema-inducing activities when injected into the foot pads of mice and induces necrosis of muscle cells when injected into the thigh muscle. Has a low enzymatic activity. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.<ref>PMID:18062812</ref> <ref>PMID:2115497</ref> <ref>PMID:8835338</ref>
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[https://www.uniprot.org/uniprot/PA2B8_DABRR PA2B8_DABRR] Snake venom phospholipase A2 (PLA2) that shows weak neurotoxicity and medium anticoagulant effects by binding to factor Xa (F10) and inhibiting the prothrombinase activity (IC(50) is 130 nM) (PubMed:18062812). It also damages vital organs such as lung, liver and kidney, displays edema-inducing activities when injected into the foot pads of mice and induces necrosis of muscle cells when injected into the thigh muscle. Has a low enzymatic activity. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.<ref>PMID:18062812</ref> <ref>PMID:2115497</ref> <ref>PMID:8835338</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Daboia russellii pulchella]]
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[[Category: Daboia russelii pulchella]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Damodar, N C]]
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[[Category: Damodar NC]]
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[[Category: Haridas, M]]
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[[Category: Haridas M]]
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[[Category: Jain, R]]
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[[Category: Jain R]]
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[[Category: Kaur, P]]
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[[Category: Kaur P]]
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[[Category: Kumar, S]]
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[[Category: Kumar S]]
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[[Category: Sharma, S]]
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[[Category: Sharma S]]
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[[Category: Singh, N]]
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[[Category: Singh N]]
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[[Category: Singh, T P]]
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[[Category: Singh TP]]
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[[Category: Srinivasan, A]]
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[[Category: Srinivasan A]]
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[[Category: Aerva lanata]]
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[[Category: Calcium]]
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[[Category: Complex]]
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[[Category: Daucosterol]]
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[[Category: Hydrolase]]
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[[Category: Lipid degradation]]
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[[Category: Metal-binding]]
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[[Category: Neurotoxin]]
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[[Category: Phospholipse a2]]
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[[Category: Presynaptic neurotoxin]]
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[[Category: Secreted]]
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[[Category: Toxin]]
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Current revision

Crystal structure of the complex of phospholipase A2 with Bavachalcone from Aerva lanata at 2.6 A resolution

PDB ID 2zbh

Drag the structure with the mouse to rotate

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OCA

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