1ca2

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[[Image:1ca2.gif|left|200px]]
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==Overview==
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{{ABSTRACT_3151019}}
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The structure of human erythrocytic carbonic anhydrase II has been refined by constrained and restrained structure-factor least-squares refinement at 2.0 A resolution. The conventional crystallographic R value is 17.3%. Of 167 solvent molecules associated with the protein, four are buried and stabilize secondary structure elements. The zinc ion is ligated to three histidyl residues and one water molecule in a nearly tetrahedral geometry. In addition to the zinc-bound water, seven more water molecules are identified in the active site. Assuming that Glu-106 is deprotonated at pH 8.5, some of the hydrogen bond donor-acceptor relations in the active site can be assigned and are described here in detail. The O gamma 1 atom of Thr-199 donates its proton to the O epsilon 1 atom of Glu-106 and can function as a hydrogen bond acceptor only in additional hydrogen bonds.
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==About this Structure==
==About this Structure==
1CA2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1cac 1cac]. The following page contains interesting information on the relation of 1CA2 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb49_1.html Carbonic Anhydrase]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CA2 OCA].
1CA2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1cac 1cac]. The following page contains interesting information on the relation of 1CA2 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb49_1.html Carbonic Anhydrase]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CA2 OCA].
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==Reference==
 
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Refined structure of human carbonic anhydrase II at 2.0 A resolution., Eriksson AE, Jones TA, Liljas A, Proteins. 1988;4(4):274-82. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/3151019 3151019]
 
[[Category: Carbonate dehydratase]]
[[Category: Carbonate dehydratase]]
[[Category: Carbonic Anhydrase]]
[[Category: Carbonic Anhydrase]]
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[[Category: Jones, T A.]]
[[Category: Jones, T A.]]
[[Category: Liljas, A.]]
[[Category: Liljas, A.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:07:12 2008''

Revision as of 14:07, 26 June 2008

Image:1ca2.png


PDB ID 1ca2

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1ca2, resolution 2.00Å ()
Ligands:
Activity: Carbonate dehydratase, with EC number 4.2.1.1
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



REFINED STRUCTURE OF HUMAN CARBONIC ANHYDRASE II AT 2.0 ANGSTROMS RESOLUTION


Template:ABSTRACT 3151019

About this Structure

1CA2 is a Single protein structure of sequence from Homo sapiens. This structure supersedes the now removed PDB entry 1cac. The following page contains interesting information on the relation of 1CA2 with [Carbonic Anhydrase]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:07:12 2008

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