5kr7

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Current revision (10:52, 27 September 2023) (edit) (undo)
 
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<StructureSection load='5kr7' size='340' side='right'caption='[[5kr7]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='5kr7' size='340' side='right'caption='[[5kr7]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5kr7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KR7 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5KR7 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5kr7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KR7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KR7 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6X9:6-ETHYL-2,5-DIMETHYL-7-OXIDANYLIDENE-4~{H}-PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBONITRILE'>6X9</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KDM4C, GASC1, JHDM3C, JMJD2C, KIAA0780 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6X9:6-ETHYL-2,5-DIMETHYL-7-OXIDANYLIDENE-4~{H}-PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBONITRILE'>6X9</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5kr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kr7 OCA], [http://pdbe.org/5kr7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kr7 RCSB], [http://www.ebi.ac.uk/pdbsum/5kr7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kr7 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5kr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kr7 OCA], [https://pdbe.org/5kr7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5kr7 RCSB], [https://www.ebi.ac.uk/pdbsum/5kr7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5kr7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/KDM4C_HUMAN KDM4C_HUMAN]] Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.<ref>PMID:16603238</ref>
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[https://www.uniprot.org/uniprot/KDM4C_HUMAN KDM4C_HUMAN] Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.<ref>PMID:16603238</ref>
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bellon, S F]]
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[[Category: Bellon SF]]
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[[Category: Poy, F]]
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[[Category: Poy F]]
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[[Category: Setser, J W]]
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[[Category: Setser JW]]
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[[Category: Histone]]
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[[Category: Inhibitor]]
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[[Category: Lysine demethylase]]
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[[Category: Oxidoreductase]]
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Current revision

KDM4C bound to pyrazolo-pyrimidine scaffold

PDB ID 5kr7

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