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5l01

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Current revision (12:46, 4 October 2023) (edit) (undo)
 
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<StructureSection load='5l01' size='340' side='right'caption='[[5l01]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='5l01' size='340' side='right'caption='[[5l01]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5l01]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L01 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5L01 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5l01]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L01 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5L01 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6Z4:(3~{S})-8-[2-AZANYL-6-[(1~{R})-1-(4-CHLORANYL-2-PHENYL-PHENYL)-2,2,2-TRIS(FLUORANYL)ETHOXY]PYRIMIDIN-4-YL]-2,8-DIAZASPIRO[4.5]DECANE-3-CARBOXYLIC+ACID'>6Z4</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5j6d|5j6d]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6Z4:(3~{S})-8-[2-AZANYL-6-[(1~{R})-1-(4-CHLORANYL-2-PHENYL-PHENYL)-2,2,2-TRIS(FLUORANYL)ETHOXY]PYRIMIDIN-4-YL]-2,8-DIAZASPIRO[4.5]DECANE-3-CARBOXYLIC+ACID'>6Z4</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TPH1, TPH, TPRH, TRPH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5l01 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l01 OCA], [https://pdbe.org/5l01 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5l01 RCSB], [https://www.ebi.ac.uk/pdbsum/5l01 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5l01 ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptophan_5-monooxygenase Tryptophan 5-monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.16.4 1.14.16.4] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5l01 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l01 OCA], [http://pdbe.org/5l01 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l01 RCSB], [http://www.ebi.ac.uk/pdbsum/5l01 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l01 ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TPH1_HUMAN TPH1_HUMAN]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Tryptophan 5-monooxygenase]]
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[[Category: De Lombaert S]]
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[[Category: Goldberg, D R]]
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[[Category: Goldberg DR]]
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[[Category: Holt, M C]]
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[[Category: Holt MC]]
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[[Category: Lombaert, S De]]
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[[Category: Stein AJ]]
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[[Category: Stein, A J]]
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[[Category: Acyl]]
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[[Category: Iron]]
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[[Category: Oxidoreductase-inhibitor complex]]
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[[Category: Quanidine]]
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[[Category: Tph1]]
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Current revision

Tryptophan 5-hydroxylase in complex with inhibitor (3~{S})-8-[2-azanyl-6-[(1~{R})-1-(4-chloranyl-2-phenyl-phenyl)-2,2,2-tris(fluoranyl)ethoxy]pyrimidin-4-yl]-2,8-diazaspiro[4.5]decane-3-carboxylic acid

PDB ID 5l01

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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