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5l7w

From Proteopedia

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Current revision (16:10, 4 October 2023) (edit) (undo)
 
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<StructureSection load='5l7w' size='340' side='right'caption='[[5l7w]], [[Resolution|resolution]] 1.76&Aring;' scene=''>
<StructureSection load='5l7w' size='340' side='right'caption='[[5l7w]], [[Resolution|resolution]] 1.76&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5l7w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L7W OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5L7W FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5l7w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L7W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5L7W FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6QU:[4-FLUORANYL-2,3-BIS(OXIDANYL)PHENYL]-[6-(2-FLUORANYL-3-OXIDANYL-PHENYL)PYRIDIN-2-YL]METHANONE'>6QU</scene>, <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.76&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HSD17B14, DHRS10, SDR3, SDR47C1, UNQ502/PRO474 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6QU:[4-FLUORANYL-2,3-BIS(OXIDANYL)PHENYL]-[6-(2-FLUORANYL-3-OXIDANYL-PHENYL)PYRIDIN-2-YL]METHANONE'>6QU</scene>, <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5l7w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l7w OCA], [http://pdbe.org/5l7w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l7w RCSB], [http://www.ebi.ac.uk/pdbsum/5l7w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l7w ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5l7w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l7w OCA], [https://pdbe.org/5l7w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5l7w RCSB], [https://www.ebi.ac.uk/pdbsum/5l7w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5l7w ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DHB14_HUMAN DHB14_HUMAN]] Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3-beta,17-beta-diol (in vitro).<ref>PMID:17067289</ref>
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[https://www.uniprot.org/uniprot/DHB14_HUMAN DHB14_HUMAN] Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3-beta,17-beta-diol (in vitro).<ref>PMID:17067289</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bertoletti, N]]
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[[Category: Bertoletti N]]
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[[Category: Braun, F]]
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[[Category: Braun F]]
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[[Category: Heine, A]]
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[[Category: Heine A]]
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[[Category: Klebe, G]]
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[[Category: Klebe G]]
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[[Category: Marchais-Oberwinkler, S]]
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[[Category: Marchais-Oberwinkler S]]
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[[Category: Hydroxysteroid dehydrogenase]]
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[[Category: Inhibitor complex]]
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[[Category: Oxidoreductase]]
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Current revision

17beta-hydroxysteroid dehydrogenase 14 variant T205 in complex with a non-steroidal inhibitor.

PDB ID 5l7w

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