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| | <StructureSection load='5lbh' size='340' side='right'caption='[[5lbh]], [[Resolution|resolution]] 2.55Å' scene=''> | | <StructureSection load='5lbh' size='340' side='right'caption='[[5lbh]], [[Resolution|resolution]] 2.55Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[5lbh]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/"helicobacter_westmeadii"_trivett-moore_et_al._1997 "helicobacter westmeadii" trivett-moore et al. 1997]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LBH OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5LBH FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5lbh]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_cinaedi Helicobacter cinaedi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LBH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LBH FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.553Å</td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HCN_0606 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=213 "Helicobacter westmeadii" Trivett-Moore et al. 1997])</td></tr> | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5lbh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lbh OCA], [http://pdbe.org/5lbh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lbh RCSB], [http://www.ebi.ac.uk/pdbsum/5lbh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lbh ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lbh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lbh OCA], [https://pdbe.org/5lbh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lbh RCSB], [https://www.ebi.ac.uk/pdbsum/5lbh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lbh ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/I7H4K9_9HELI I7H4K9_9HELI] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Helicobacter westmeadii trivett-moore et al. 1997]] | + | [[Category: Helicobacter cinaedi]] |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Bernard, M De]] | + | [[Category: Codolo G]] |
| - | [[Category: Codolo, G]] | + | [[Category: De Bernard M]] |
| - | [[Category: Valesse, F]] | + | [[Category: Valesse F]] |
| - | [[Category: Zanotti, G]] | + | [[Category: Zanotti G]] |
| - | [[Category: Dps-like protein neutrophile activating protein mini-ferritin]]
| + | |
| - | [[Category: Transport protein]]
| + | |
| Structural highlights
Function
I7H4K9_9HELI
Publication Abstract from PubMed
Recent studies have shown that certain specific microbial infections participate in atherosclerosis by inducing inflammation and immune reactions, but how the pathogens implicated in this pathology trigger the host responses remains unknown. In this study we show that Helicobacter cinaedi (Hc) is a human pathogen linked to atherosclerosis development since at least 27% of sera from atherosclerotic patients specifically recognize a protein of the Hc proteome, that we named Cinaedi Atherosclerosis Inflammatory Protein (CAIP) (n = 71). CAIP appears to be implicated in this pathology because atheromatous plaques isolated from atherosclerotic patients are enriched in CAIP-specific T cells (10%) which, in turn, we show to drive a Th1 inflammation, an immunopathological response typically associated to atherosclerosis. Recombinant CAIP promotes the differentiation and maintenance of the pro-inflammatory profile of human macrophages and triggers the formation of foam cells, which are a hallmark of atherosclerosis. This study identifies CAIP as a relevant factor in atherosclerosis inflammation linked to Hc infection and suggests that preventing and eradicating Hc infection could reduce the incidence of atherosclerosis.
The Helicobacter cinaedi antigen CAIP participates in atherosclerotic inflammation by promoting the differentiation of macrophages in foam cells.,D'Elios MM, Vallese F, Capitani N, Benagiano M, Bernardini ML, Rossi M, Rossi GP, Ferrari M, Baldari CT, Zanotti G, de Bernard M, Codolo G Sci Rep. 2017 Jan 11;7:40515. doi: 10.1038/srep40515. PMID:28074932[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ D'Elios MM, Vallese F, Capitani N, Benagiano M, Bernardini ML, Rossi M, Rossi GP, Ferrari M, Baldari CT, Zanotti G, de Bernard M, Codolo G. The Helicobacter cinaedi antigen CAIP participates in atherosclerotic inflammation by promoting the differentiation of macrophages in foam cells. Sci Rep. 2017 Jan 11;7:40515. doi: 10.1038/srep40515. PMID:28074932 doi:http://dx.doi.org/10.1038/srep40515
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