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5lef

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Current revision (08:57, 11 October 2023) (edit) (undo)
 
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<StructureSection load='5lef' size='340' side='right'caption='[[5lef]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
<StructureSection load='5lef' size='340' side='right'caption='[[5lef]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5lef]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LEF OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5LEF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5lef]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LEF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LEF FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.088&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5lef FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lef OCA], [http://pdbe.org/5lef PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lef RCSB], [http://www.ebi.ac.uk/pdbsum/5lef PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lef ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lef FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lef OCA], [https://pdbe.org/5lef PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lef RCSB], [https://www.ebi.ac.uk/pdbsum/5lef PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lef ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RAB6A_HUMAN RAB6A_HUMAN]] Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity. [[http://www.uniprot.org/uniprot/KI20A_MOUSE KI20A_MOUSE]] Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle (By similarity). Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility.<ref>PMID:9438855</ref>
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[https://www.uniprot.org/uniprot/RAB6A_HUMAN RAB6A_HUMAN] Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Kinesin 3D Structures|Kinesin 3D Structures]]
*[[Kinesin 3D Structures|Kinesin 3D Structures]]
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*[[Ras-related protein Rab 3D structures|Ras-related protein Rab 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bressanelli, G]]
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[[Category: Mus musculus]]
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[[Category: Houdusse, A]]
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[[Category: Bressanelli G]]
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[[Category: Pylypenko, O]]
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[[Category: Houdusse A]]
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[[Category: Kinesin]]
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[[Category: Pylypenko O]]
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[[Category: Motor]]
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[[Category: Protein complex]]
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[[Category: Protein transport]]
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[[Category: Rab gtpase]]
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Current revision

Rab6A:Kif20A complex

PDB ID 5lef

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