User:Isabela Fonseca de Oliveira Granha/Sandbox 1

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[[Image:Beta-catenin-moonlighting.png]]
[[Image:Beta-catenin-moonlighting.png]]
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'''Figure 4''': Cadherin-based cell adhesion. Alpha-catenin/ß-catenin forms a heterodimer that can connects to E-cadherin promoting the adherens junctions. As a homodimer, alpha-catenin interacts with actin. Adapted from: Bubus12/CC BY ([https://commons.wikimedia.org/wiki/File:Beta-catenin-moonlighting.png])
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'''Figure 4''': Cadherin-based cell adhesion. Alpha-catenin/ß-catenin forms a heterodimer that can connects to E-cadherin promoting the adherens junctions. As a homodimer, alpha-catenin interacts with actin. Adapted from: Bubus12/CC BY [https://commons.wikimedia.org/wiki/File:Beta-catenin-moonlighting.png]
==The ß-catenin destruction complex==
==The ß-catenin destruction complex==
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[[Image:Axindestructioncomplex.png]]
[[Image:Axindestructioncomplex.png]]
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'''Figure 5''': A simplified diagram of the ß-catenin destruction complex. The destruction complex proteins promote the ß-catenin proteolysis in cytoplasm. Source: JWSchmidt at the English language Wikipedia/CC BY-SA ([https://commons.wikimedia.org/wiki/File:Axindestructioncomplex.png])
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'''Figure 5''': A simplified diagram of the ß-catenin destruction complex. The destruction complex proteins promote the ß-catenin proteolysis in cytoplasm. Source: JWSchmidt at the English language Wikipedia/CC BY-SA [https://commons.wikimedia.org/wiki/File:Axindestructioncomplex.png]
==DNA binding and transcription==
==DNA binding and transcription==
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[[Image:Canonical Wnt pathway with Wnt..jpg]]
[[Image:Canonical Wnt pathway with Wnt..jpg]]
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'''Figure 6''': The canonical Wnt pathway when Wnt is present. The inhibition of the destruction complex allows ß-catenin translocation from cytoplasm to nucleus. Source: Gpruett2/CC BY-SA ([https://commons.wikimedia.org/wiki/File:Canonical_Wnt_pathway_with_Wnt..jpg])
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'''Figure 6''': The canonical Wnt pathway when Wnt is present. The inhibition of the destruction complex allows ß-catenin translocation from cytoplasm to nucleus. Source: Gpruett2/CC BY-SA [https://commons.wikimedia.org/wiki/File:Canonical_Wnt_pathway_with_Wnt..jpg]
== References ==
== References ==
<references/>
<references/>

Revision as of 19:41, 10 August 2020

ß-catenin

ß-catenin is an important element in cell-cell adherens junctions, called cadherins. Reported in all Eukaryota (Eukaryota) phylum, in humans the gene CTNNB1 (CTNNB1) transcribes a 95kDa protein that allows cadherins to anchor in cytoeskeleton (actin filaments) by connecting cytoplasmic proteins. Besides that, it is an essential regulator of the canonical Wnt pathway [1] (related to embryonic development). Disturbance of this activity is associated with cancer and other diseases. Therefore, ß-catenin is an important target for developing medication for many diseases, with considerable interest in its structure. [2]

Structure of ß-catenin from Zebrafish

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

Isabela Fonseca de Oliveira Granha

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