This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1cd9

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1cd9.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1cd9.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1cd9| PDB=1cd9 | SCENE= }}
{{STRUCTURE_1cd9| PDB=1cd9 | SCENE= }}
-
'''2:2 COMPLEX OF G-CSF WITH ITS RECEPTOR'''
+
===2:2 COMPLEX OF G-CSF WITH ITS RECEPTOR===
-
==Overview==
+
<!--
-
Granulocyte colony-stimulating factor (GCSF) is the principal growth factor regulating the maturation, proliferation and differentiation of the precursor cells of neutrophilic granulocytes and is used to treat neutropenia. GCSF is a member of the long-chain subtype of the class 1 cytokine superfamily, which includes growth hormone, erythropoietin, interleukin 6 and oncostatin M. Here we have determined the crystal structure of GCSF complexed to the BN-BC domains, the principal ligand-binding region of the GCSF receptor (GCSFR). The two receptor domains form a complex in a 2:2 ratio with the ligand, with a non-crystallographic pseudo-twofold axis through primarily the interdomain region and secondarily the BC domain. This structural view of a gp130-type receptor-ligand complex presents a new molecular basis for cytokine-receptor recognition.
+
The line below this paragraph, {{ABSTRACT_PUBMED_10537111}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 10537111 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_10537111}}
==About this Structure==
==About this Structure==
Line 32: Line 36:
[[Category: Hematopoietic receptor]]
[[Category: Hematopoietic receptor]]
[[Category: Signal transduction]]
[[Category: Signal transduction]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:36:07 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:34:57 2008''

Revision as of 17:35, 30 June 2008

Image:1cd9.png

Template:STRUCTURE 1cd9

2:2 COMPLEX OF G-CSF WITH ITS RECEPTOR

Template:ABSTRACT PUBMED 10537111

About this Structure

1CD9 is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

Reference

Atomic structure of the GCSF-receptor complex showing a new cytokine-receptor recognition scheme., Aritomi M, Kunishima N, Okamoto T, Kuroki R, Ota Y, Morikawa K, Nature. 1999 Oct 14;401(6754):713-7. PMID:10537111

Page seeded by OCA on Mon Jun 30 20:34:57 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1cd9"
Personal tools