6vxm

<table><tr><td colspan='2'>[[6vxm]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VXM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6VXM FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LFA:EICOSANE'>LFA</scene></td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MSL1, At4g00290, A_IG005I10.9, F5I10.9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6vxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vxm OCA], [http://pdbe.org/6vxm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vxm RCSB], [http://www.ebi.ac.uk/pdbsum/6vxm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vxm ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/MSL1_ARATH MSL1_ARATH]] Mechanosensitive channel that opens in response to stretch forces in the membrane lipid bilayer.

Mechanosensitive ion channels transduce physical force into electrochemical signaling that underlies an array of fundamental physiological processes, including hearing, touch, proprioception, osmoregulation, and morphogenesis. The mechanosensitive channels of small conductance (MscS) constitute a remarkably diverse superfamily of channels critical for management of osmotic pressure. Here, we present cryo-electron microscopy structures of a MscS homolog from Arabidopsis thaliana, MSL1, presumably in both the closed and open states. The heptameric MSL1 channel contains an unusual bowl-shaped transmembrane region, which is reminiscent of the evolutionarily and architecturally unrelated mechanosensitive Piezo channels. Upon channel opening, the curved transmembrane domain of MSL1 flattens and expands. Our structures, in combination with functional analyses, delineate a structural mechanism by which mechanosensitive channels open under increased membrane tension. Further, the shared structural feature between unrelated channels suggests the possibility of a unified mechanical gating mechanism stemming from membrane deformation induced by a non-planar transmembrane domain.

 

== References ==

[[Category: Arath]]

[[Category: Deng, Z]]

[[Category: Yuan, P]]

[[Category: Zhang, J]]

[[Category: Transport protein]]