6mc1
From Proteopedia
(Difference between revisions)
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==Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((9-(methylthio)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor== | ==Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((9-(methylthio)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor== | ||
| - | <StructureSection load='6mc1' size='340' side='right'caption='[[6mc1]]' scene=''> | + | <StructureSection load='6mc1' size='340' side='right'caption='[[6mc1]], [[Resolution|resolution]] 2.70Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MC1 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6MC1 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6mc1]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MC1 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6MC1 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6mc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mc1 OCA], [http://pdbe.org/6mc1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mc1 RCSB], [http://www.ebi.ac.uk/pdbsum/6mc1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mc1 ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CJA:3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one'>CJA</scene>, <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene></td></tr> |
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DUSP10, MKP5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6mc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mc1 OCA], [http://pdbe.org/6mc1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mc1 RCSB], [http://www.ebi.ac.uk/pdbsum/6mc1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mc1 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DUS10_HUMAN DUS10_HUMAN]] Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily.<ref>PMID:22375048</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Anderson | + | [[Category: Anderson, K S]] |
| - | [[Category: Bennett | + | [[Category: Bennett, A M]] |
| - | [[Category: Gannam | + | [[Category: Gannam, Z T.K]] |
| - | [[Category: Lolis E]] | + | [[Category: Lolis, E]] |
| + | [[Category: Dual specificity phosphatase]] | ||
| + | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||
| + | [[Category: Phosphatase]] | ||
| + | [[Category: Phosphatase-inhibitor complex]] | ||
| + | [[Category: Protein-tyrosine phosphatase]] | ||
Revision as of 07:02, 2 September 2020
Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((9-(methylthio)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor
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