7brc

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==Crystal structure of the TMK3 LRR domain==
==Crystal structure of the TMK3 LRR domain==
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<StructureSection load='7brc' size='340' side='right'caption='[[7brc]]' scene=''>
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<StructureSection load='7brc' size='340' side='right'caption='[[7brc]], [[Resolution|resolution]] 2.06&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BRC OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7BRC FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7brc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BRC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BRC FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7brc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7brc OCA], [http://pdbe.org/7brc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7brc RCSB], [http://www.ebi.ac.uk/pdbsum/7brc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7brc ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.06&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7brc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7brc OCA], [https://pdbe.org/7brc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7brc RCSB], [https://www.ebi.ac.uk/pdbsum/7brc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7brc ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TMK3_ARATH TMK3_ARATH] Involved in auxin signal transduction and cell expansion and proliferation regulation (PubMed:23613767).<ref>PMID:23613767</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Transmembrane kinases (TMKs) are members of the plant receptor-like kinase (RLK) family. TMKs are characterized by an extracellular leucine-rich-repeat (LRR) domain, a single transmembrane region and a cytoplasmic kinase domain. TMKs have been shown to act as critical modulators of cell expansion and cell proliferation. Here, the crystal structure of the extracellular domain of TMK3 (TMK3-ECD) was determined to a resolution of 2.06 A, with an Rwork of 17.69% and an Rfree of 20.58%. Similar to the extracellular domain of TMK1, the TMK3-ECD structure contains two solenoids with 13 LRRs and a non-LRR region (316-364) between the tenth and 11th LRRs. A comparison of TMK3-ECD with other LRR-RLKs that contain a non-LRR region indicates that the non-LRR region plays a critical role in structural integrity and may contribute to ligand interactions. The non-LRR region of TMK3-ECD is characterized by two disulfide bonds that may have critical biological implications.
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Crystal structure of the extracellular domain of the receptor-like kinase TMK3 from Arabidopsis thaliana.,Chen H, Kong Y, Chen J, Li L, Li X, Yu F, Ming Z Acta Crystallogr F Struct Biol Commun. 2020 Aug 1;76(Pt 8):384-390. doi:, 10.1107/S2053230X20010122. Epub 2020 Jul 29. PMID:32744250<ref>PMID:32744250</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 7brc" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Arabidopsis thaliana]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Chen H]]
[[Category: Chen H]]

Revision as of 15:27, 29 November 2023

Crystal structure of the TMK3 LRR domain

PDB ID 7brc

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