7c51
From Proteopedia
(Difference between revisions)
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==Crystal structure of a Simpl-like protein from Campylobacter jejuni (native protein)== | ==Crystal structure of a Simpl-like protein from Campylobacter jejuni (native protein)== | ||
| - | <StructureSection load='7c51' size='340' side='right'caption='[[7c51]]' scene=''> | + | <StructureSection load='7c51' size='340' side='right'caption='[[7c51]], [[Resolution|resolution]] 2.46Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7C51 OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[7c51]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Campylobacter_jejuni Campylobacter jejuni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7C51 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7C51 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.46Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7c51 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7c51 OCA], [https://pdbe.org/7c51 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7c51 RCSB], [https://www.ebi.ac.uk/pdbsum/7c51 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7c51 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A0A3Z9IF87_CAMJU A0A3Z9IF87_CAMJU] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Signaling molecule that interacts with mouse pelle-like kinase (Simpl) is an animal protein that contributes to the regulation of inflammatory responses. Although Simpl-like proteins (SLPs) are mainly found in bacteria, functional and structural studies on bacterial SLPs are limited to BP26, a periplasmic protein from Brucella species. We identified a group of bacterial SLPs, including Campylobacter jejuni SLP (cjSLP) and Shewanella putrefaciens SLP (spSLP), that exhibit significant sequence variation from Simpl and BP26. To address the structural and oligomeric diversities of SLPs, we determined the crystal structure of cjSLP and performed a comparative analysis of SLP structures. cjSLP adopts a boomerang-shaped, two-domain structure, and each domain of cjSLP adopts an alpha-helix-decorated beta-sheet structure as observed in BP26. This observation suggests that the duplicated alpha/beta structure would be the canonical fold of the Simpl family. Despite the fold similarity, cjSLP exhibits a more open interdomain organization than BP26 and displays unique local structural features that are not observed in BP26. Furthermore, cjSLP and its ortholog spSLP are monomeric in solution in contrast to the hexadecameric assembly of BP26. Therefore, we conclude that cjSLP represents a unique bacterial SLP group that is distinct from BP26 in both structures and oligomeric states. | ||
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| + | Structural analysis of a Simpl-like protein from Campylobacter jejuni.,Oh HB, Yoon SI Biochem Biophys Res Commun. 2020 Aug 20;529(2):270-276. doi:, 10.1016/j.bbrc.2020.05.211. Epub 2020 Jun 23. PMID:32703422<ref>PMID:32703422</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7c51" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Campylobacter jejuni]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Oh HB]] | [[Category: Oh HB]] | ||
[[Category: Yoon SI]] | [[Category: Yoon SI]] | ||
Current revision
Crystal structure of a Simpl-like protein from Campylobacter jejuni (native protein)
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