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6wg5

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Current revision (14:24, 18 October 2023) (edit) (undo)
 
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<StructureSection load='6wg5' size='340' side='right'caption='[[6wg5]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='6wg5' size='340' side='right'caption='[[6wg5]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6wg5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WG5 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6WG5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6wg5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WG5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WG5 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ENTPD4, KIAA0392, LALP70, LYSAL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nucleoside_diphosphate_phosphatase Nucleoside diphosphate phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.6 3.6.1.6] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wg5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wg5 OCA], [https://pdbe.org/6wg5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wg5 RCSB], [https://www.ebi.ac.uk/pdbsum/6wg5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wg5 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6wg5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wg5 OCA], [http://pdbe.org/6wg5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6wg5 RCSB], [http://www.ebi.ac.uk/pdbsum/6wg5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6wg5 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ENTP4_HUMAN ENTP4_HUMAN]] Hydrolyzes preferentially nucleoside 5'-diphosphates, nucleoside 5'-triphosphates are hydrolyzed only to a minor extent. The order of activity with different substrates is UDP >> GDP = CDP = TDP, AMP, ADP, ATP and UMP are not substrates. Preferred substrates for isoform 2 are CTP, UDP, CDP, GTP and GDP, while isoform 1 utilizes UTP and TTP.
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[https://www.uniprot.org/uniprot/ENTP4_HUMAN ENTP4_HUMAN] Hydrolyzes preferentially nucleoside 5'-diphosphates, nucleoside 5'-triphosphates are hydrolyzed only to a minor extent. The order of activity with different substrates is UDP >> GDP = CDP = TDP, AMP, ADP, ATP and UMP are not substrates. Preferred substrates for isoform 2 are CTP, UDP, CDP, GTP and GDP, while isoform 1 utilizes UTP and TTP.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6wg5" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6wg5" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Ectonucleoside triphosphate diphosphohydrolase|Ectonucleoside triphosphate diphosphohydrolase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Nucleoside diphosphate phosphatase]]
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[[Category: Gorelik A]]
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[[Category: Gorelik, A]]
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[[Category: Illes K]]
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[[Category: Illes, K]]
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[[Category: Labriola JM]]
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[[Category: Labriola, J M]]
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[[Category: Nagar B]]
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[[Category: Nagar, B]]
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[[Category: Askha superfamily]]
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[[Category: Glycosylation]]
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[[Category: Hydrolase]]
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[[Category: Nucleotide metabolism]]
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Current revision

Human ectonucleoside triphosphate diphosphohydrolase 4 (ENTPD4, NTPDase 4)

PDB ID 6wg5

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