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5mae

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<StructureSection load='5mae' size='340' side='right'caption='[[5mae]], [[Resolution|resolution]] 1.00&Aring;' scene=''>
<StructureSection load='5mae' size='340' side='right'caption='[[5mae]], [[Resolution|resolution]] 1.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5mae]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MAE OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5MAE FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5mae]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MAE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MAE FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7KN:[4-[CYCLOPENTYL(PYRAZIN-2-YLMETHYL)AMINO]-6-MORPHOLIN-4-YL-1,3,5-TRIAZIN-2-YL]METHYLIDENEAZANIDE'>7KN</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CTSL, CTSL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7KN:[4-[CYCLOPENTYL(PYRAZIN-2-YLMETHYL)AMINO]-6-MORPHOLIN-4-YL-1,3,5-TRIAZIN-2-YL]METHYLIDENEAZANIDE'>7KN</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_L Cathepsin L], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.15 3.4.22.15] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mae FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mae OCA], [https://pdbe.org/5mae PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mae RCSB], [https://www.ebi.ac.uk/pdbsum/5mae PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mae ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5mae FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mae OCA], [http://pdbe.org/5mae PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mae RCSB], [http://www.ebi.ac.uk/pdbsum/5mae PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mae ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CATL1_HUMAN CATL1_HUMAN]] Important for the overall degradation of proteins in lysosomes.
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[https://www.uniprot.org/uniprot/CATL1_HUMAN CATL1_HUMAN] Important for the overall degradation of proteins in lysosomes.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cathepsin L]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Benz, J]]
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[[Category: Benz J]]
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[[Category: Kuglstatter, A]]
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[[Category: Kuglstatter A]]
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[[Category: Stihle, M]]
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[[Category: Stihle M]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Protease inhibitor]]
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Revision as of 18:34, 1 November 2023

CATHEPSIN L IN COMPLEX WITH (2S,4R)-4-(2-Chloro-4-methoxy-benzenesulfonyl)-1-[3-(5-chloro-pyridin-2-yl)-azetidine-3-carbonyl]-pyrrolidine-2-car boxylic acid (1-cyano-cyclopropyl)-amide

PDB ID 5mae

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