5mmv

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Current revision (17:40, 8 November 2023) (edit) (undo)
 
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<StructureSection load='5mmv' size='340' side='right'caption='[[5mmv]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
<StructureSection load='5mmv' size='340' side='right'caption='[[5mmv]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5mmv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MMV OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5MMV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5mmv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MMV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MMV FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=WE0:(3~{S})-3-[[(3~{S})-2-[(2~{S})-3-methyl-2-(naphthalen-2-ylcarbonylamino)butanoyl]-4-oxidanyl-2-azabicyclo[2.2.2]octan-3-yl]carbonylamino]-4-oxidanyl-butanoic+acid'>WE0</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-1 Caspase-1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.36 3.4.22.36] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=WE0:(3~{S})-3-[[(3~{S})-2-[(2~{S})-3-methyl-2-(naphthalen-2-ylcarbonylamino)butanoyl]-4-oxidanyl-2-azabicyclo[2.2.2]octan-3-yl]carbonylamino]-4-oxidanyl-butanoic+acid'>WE0</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5mmv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mmv OCA], [http://pdbe.org/5mmv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mmv RCSB], [http://www.ebi.ac.uk/pdbsum/5mmv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mmv ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mmv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mmv OCA], [https://pdbe.org/5mmv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mmv RCSB], [https://www.ebi.ac.uk/pdbsum/5mmv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mmv ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CASP1_HUMAN CASP1_HUMAN]] Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.<ref>PMID:7876192</ref> <ref>PMID:15498465</ref>
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[https://www.uniprot.org/uniprot/CASP1_HUMAN CASP1_HUMAN] Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.<ref>PMID:7876192</ref> <ref>PMID:15498465</ref>
==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Caspase-1]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Brethon, A]]
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[[Category: Brethon A]]
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[[Category: Chantalat, L]]
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[[Category: Chantalat L]]
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[[Category: Christin, O]]
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[[Category: Christin O]]
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[[Category: Clary, L]]
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[[Category: Clary L]]
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[[Category: Fournier, J F]]
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[[Category: Fournier JF]]
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[[Category: Gastreich, M]]
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[[Category: Gastreich M]]
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[[Category: Harris, C]]
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[[Category: Harris C]]
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[[Category: Isabet, T]]
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[[Category: Isabet T]]
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[[Category: Pascau, J]]
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[[Category: Pascau J]]
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[[Category: Roche, D]]
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[[Category: Roche D]]
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[[Category: Rodeschin, V]]
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[[Category: Rodeschin V]]
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[[Category: Thoreau, E]]
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[[Category: Thoreau E]]
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[[Category: Hydrolase]]
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[[Category: Inflammatory disease]]
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[[Category: Nanomolar inhibitor]]
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[[Category: Sp3 hybridization]]
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Current revision

Crystal structure of human Caspase-1 with 2-((2-naphthoyl)-L-valyl)-4-hydroxy-N-((3S)-2-hydroxy-5-oxotetrahydrofuran-3-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide (Compound 1)

PDB ID 5mmv

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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