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5mub
From Proteopedia
(Difference between revisions)
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<StructureSection load='5mub' size='340' side='right'caption='[[5mub]], [[Resolution|resolution]] 3.10Å' scene=''> | <StructureSection load='5mub' size='340' side='right'caption='[[5mub]], [[Resolution|resolution]] 3.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5mub]] is a 24 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[5mub]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MUB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MUB FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIR:CITRULLINE'>CIR</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mub FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mub OCA], [https://pdbe.org/5mub PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mub RCSB], [https://www.ebi.ac.uk/pdbsum/5mub PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mub ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/CO2A1_MOUSE CO2A1_MOUSE] Defects in Col2a1 are the cause of a phenotype resembling human spondyloepiphyseal dysplasia congenita (sedc). Homozygous sedc mice can be identified at birth by their small size and shortened trunk. Adults have shortened noses, dysplastic vertebrae, femora and tibias, and retinoschisis and hearing loss. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CO2A1_MOUSE CO2A1_MOUSE] Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Dobritzsch | + | [[Category: Dobritzsch D]] |
| - | [[Category: Ge | + | [[Category: Ge C]] |
| - | [[Category: Holmdahl | + | [[Category: Holmdahl R]] |
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Current revision
ACC1 Fab fragment in complex with citrullinated C1 epitope of CII (CG05)
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