1cg8

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[[Image:1cg8.jpg|left|200px]]
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{{Seed}}
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{{STRUCTURE_1cg8| PDB=1cg8 | SCENE= }}
{{STRUCTURE_1cg8| PDB=1cg8 | SCENE= }}
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'''CO Form Hemoglobin from Dasyatis Akajei'''
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===CO Form Hemoglobin from Dasyatis Akajei===
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==Overview==
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The three-dimensional structures of the deoxy- and carbonmonoxyhaemoglobin (Hb) from Dasyatis akajei, a stingray, have been determined at 1.6 and 1.9 A resolution, respectively. This is one of the most distantly related vertebrate Hbs to human HbA. Both structures resemble the respective forms of HbA, indicating that the alpha2beta2-type tetramer and the mode of the quaternary structure change are common to Hbs of jawed vertebrates. Larger deviations between D. akajei Hb and human HbA are observed in various parts of the molecule, even in the E and F helices. Significant mutations and/or conformational changes are also observed around the haems, in the C-terminal region of the beta subunit, in the alpha1beta2 interface and in the organic phosphate-binding site of HbA. Despite these structural differences, the oxygen affinity, haem-haem interaction, Bohr effect and organic phosphate effect of D. akajei Hb are all only moderately reduced. Compared with human HbA, the overall r.m.s. deviation of main-chain atoms in the helical regions of bony fish Hbs is smaller than that of D. akajei Hb.
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The line below this paragraph, {{ABSTRACT_PUBMED_10393295}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10393295 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10393295}}
==About this Structure==
==About this Structure==
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[[Category: Morimoto, H.]]
[[Category: Morimoto, H.]]
[[Category: Oxygen transport]]
[[Category: Oxygen transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:42:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:42:28 2008''

Revision as of 17:42, 30 June 2008

Image:1cg8.png

Template:STRUCTURE 1cg8

CO Form Hemoglobin from Dasyatis Akajei

Template:ABSTRACT PUBMED 10393295

About this Structure

1CG8 is a Protein complex structure of sequences from Dasyatis akajei. Full crystallographic information is available from OCA.

Reference

Structures of the deoxy and CO forms of haemoglobin from Dasyatis akajei, a cartilaginous fish., Chong KT, Miyazaki G, Morimoto H, Oda Y, Park SY, Acta Crystallogr D Biol Crystallogr. 1999 Jul;55(Pt 7):1291-300. PMID:10393295

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