1cgc

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1cgc.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1cgc.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1cgc| PDB=1cgc | SCENE= }}
{{STRUCTURE_1cgc| PDB=1cgc | SCENE= }}
-
'''DOUBLE HELIX CONFORMATION GROOVE DIMENSIONS AND LIGAND BINDING POTENTIAL OF A G/C-STRETCH IN B-DNA'''
+
===DOUBLE HELIX CONFORMATION GROOVE DIMENSIONS AND LIGAND BINDING POTENTIAL OF A G/C-STRETCH IN B-DNA===
-
==Overview==
+
<!--
-
The self-complementary DNA fragment CCGGCGCCGG crystallizes in the rhombohedral space group R3 with unit cell parameters a = 54.07 A and c = 44.59 A. The structure has been determined by X-ray diffraction methods at 2.2 A resolution and refined to an R value of 16.7%. In the crystal, the decamer forms B-DNA double helices with characteristic groove dimensions: compared with B-DNA of random sequence, the minor groove is wide and deep and the major groove is rather shallow. Local base pair geometries and stacking patterns are within the range commonly observed in B-DNA crystal structures. The duplex bears no resemblance to A-form DNA as might have been expected for a sequence with only GC base pairs. The shallow major groove permits an unusual crystal packing pattern with several direct intermolecular hydrogen bonds between phosphate oxygens and cytosine amino groups. In addition, decameric duplexes form quasi-infinite double helices in the crystal by end-to-end stacking. The groove geometries and accessibilities of this molecule as observed in the crystal may be important for the mode of binding of both proteins and drug molecules to G/C stretches in DNA.
+
The line below this paragraph, {{ABSTRACT_PUBMED_1582421}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 1582421 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_1582421}}
==About this Structure==
==About this Structure==
Line 24: Line 28:
[[Category: B-dna]]
[[Category: B-dna]]
[[Category: Double helix]]
[[Category: Double helix]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:42:22 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:42:44 2008''

Revision as of 17:42, 30 June 2008

Image:1cgc.png

Template:STRUCTURE 1cgc

DOUBLE HELIX CONFORMATION GROOVE DIMENSIONS AND LIGAND BINDING POTENTIAL OF A G/C-STRETCH IN B-DNA

Template:ABSTRACT PUBMED 1582421

About this Structure

Full crystallographic information is available from OCA.

Reference

Double helix conformation, groove dimensions and ligand binding potential of a G/C stretch in B-DNA., Heinemann U, Alings C, Bansal M, EMBO J. 1992 May;11(5):1931-9. PMID:1582421

Page seeded by OCA on Mon Jun 30 20:42:44 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1cgc"
Personal tools