6t2s

<table><tr><td colspan='2'>[[6t2s]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacteroides_finegoldii_199 Bacteroides finegoldii 199]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6T2S OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6T2S FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DXB57_07550 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=483215 Bacteroides finegoldii 199])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6t2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6t2s OCA], [http://pdbe.org/6t2s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6t2s RCSB], [http://www.ebi.ac.uk/pdbsum/6t2s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6t2s ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

The thick mucus layer of the gut provides a barrier to infiltration of the underlying epithelia by both the normal microbiota and enteric pathogens. Some members of the microbiota utilise mucin glycoproteins as a nutrient source, but a detailed understanding of the mechanisms used to breakdown these complex macromolecules is lacking. Here we describe the discovery and characterisation of endo-acting enzymes from prominent mucin-degrading bacteria that target the polyLacNAc structures within oligosaccharide side chains of both animal and human mucins. These O-glycanases are part of the large and diverse glycoside hydrolase 16 (GH16) family and are often lipoproteins, indicating that they are surface located and thus likely involved in the initial step in mucin breakdown. These data provide a significant advance in our knowledge of the mechanism of mucin breakdown by the normal microbiota. Furthermore, we also demonstrate the potential use of these enzymes as tools to explore changes in O-glycan structure in a number of intestinal disease states.

 

== References ==

[[Category: Bacteroides finegoldii 199]]

[[Category: Basle, A]]

[[Category: Berrington, J E]]

[[Category: Bolam, D N]]

[[Category: Brady, R R]]

[[Category: Chater, P]]

[[Category: Cooke, K]]

[[Category: Crouch, L I]]

[[Category: Doona, M]]

[[Category: Lamb, C A]]

[[Category: Liberato, M V]]

[[Category: Linhardt, R J]]

[[Category: Madubic, K]]

[[Category: Needham, S]]

[[Category: Spence, D I.R]]

[[Category: Ubranowicz, P A]]

[[Category: Zhang, F]]

[[Category: O-glycanase]]