5n8c

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Current revision (12:34, 15 November 2023) (edit) (undo)
 
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<StructureSection load='5n8c' size='340' side='right'caption='[[5n8c]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='5n8c' size='340' side='right'caption='[[5n8c]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5n8c]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N8C OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5N8C FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5n8c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N8C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5N8C FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8Q8:(2~{S})-3-AZANYL-2-[[(1~{R})-5-[2-[4-[[2-(HYDROXYMETHYL)IMIDAZOL-1-YL]METHYL]PHENYL]ETHYNYL]-2,3-DIHYDRO-1~{H}-INDEN-1-YL]AMINO]-3-METHYL-~{N}-OXIDANYL-BUTANAMIDE'>8Q8</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">lpxC, envA, PA4406 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8Q8:(2~{S})-3-AZANYL-2-[[(1~{R})-5-[2-[4-[[2-(HYDROXYMETHYL)IMIDAZOL-1-YL]METHYL]PHENYL]ETHYNYL]-2,3-DIHYDRO-1~{H}-INDEN-1-YL]AMINO]-3-METHYL-~{N}-OXIDANYL-BUTANAMIDE'>8Q8</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-3-O-acyl-N-acetylglucosamine_deacetylase UDP-3-O-acyl-N-acetylglucosamine deacetylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.108 3.5.1.108] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5n8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n8c OCA], [https://pdbe.org/5n8c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5n8c RCSB], [https://www.ebi.ac.uk/pdbsum/5n8c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5n8c ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5n8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n8c OCA], [http://pdbe.org/5n8c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n8c RCSB], [http://www.ebi.ac.uk/pdbsum/5n8c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n8c ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/LPXC_PSEAE LPXC_PSEAE]] Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
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[https://www.uniprot.org/uniprot/LPXC_PSEAE LPXC_PSEAE] Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: UDP-3-O-acyl-N-acetylglucosamine deacetylase]]
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[[Category: Pseudomonas aeruginosa]]
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[[Category: Andersen, O A]]
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[[Category: Andersen OA]]
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[[Category: Barker, J]]
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[[Category: Barker J]]
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[[Category: Brooks, M]]
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[[Category: Brooks M]]
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[[Category: Cheng, R K]]
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[[Category: Cheng RK]]
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[[Category: Cross, J B]]
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[[Category: Cross JB]]
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[[Category: Kwong, J]]
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[[Category: Kwong J]]
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[[Category: Ryan, M D]]
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[[Category: Ryan MD]]
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[[Category: Wood, M]]
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[[Category: Wood M]]
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[[Category: Zhang, J]]
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[[Category: Zhang J]]
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[[Category: Antibacterial]]
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[[Category: Hydrolase]]
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[[Category: Hyroxamate]]
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[[Category: Inhibitor]]
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[[Category: Lpxc]]
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Current revision

Crystal structure of Pseudomonas aeruginosa LpxC complexed with inhibitor

PDB ID 5n8c

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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