5ndd
From Proteopedia
(Difference between revisions)
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<StructureSection load='5ndd' size='340' side='right'caption='[[5ndd]], [[Resolution|resolution]] 2.80Å' scene=''> | <StructureSection load='5ndd' size='340' side='right'caption='[[5ndd]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5ndd]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[5ndd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli], [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NDD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NDD FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8TZ:(~{S})-(4-FLUORANYL-2-PROPYL-PHENYL)-(1~{H}-IMIDAZOL-2-YL)METHANOL'>8TZ</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.801Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8TZ:(~{S})-(4-FLUORANYL-2-PROPYL-PHENYL)-(1~{H}-IMIDAZOL-2-YL)METHANOL'>8TZ</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ndd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ndd OCA], [https://pdbe.org/5ndd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ndd RCSB], [https://www.ebi.ac.uk/pdbsum/5ndd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ndd ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PAR2_HUMAN PAR2_HUMAN] Receptor for trypsin and trypsin-like enzymes coupled to G proteins. Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I-kappaB kinase/NF-kappaB and Rho. Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can signal synergistically with TLR4 and probably TLR2 in inflammatory responses and modulates TLR3 signaling. Has a protective role in establishing the endothelial barrier; the activity involves coagulation factor X. Proposed to have a bronchoprotective role in airway epithelium, but also shown to compromise the airway epithelial barrier by interrupting E-cadherin adhesion. Involved in the regulation of vascular tone; activation results in hypotension presumably mediated by vasodilation. Associates with a subset of G proteins alpha subunits such as G alpha-q, G alpha-11, G alpha-14, G alpha-12 and G alpha-13, but probably not with G(o) alpha, G(i) subunit alpha-1 and G(i) subunit alpha-2. However, according to PubMed:21627585 can signal through G(i) subunit alpha. Believed to be a class B receptor which internalizes as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptor, for extended periods of time. Mediates inhibition of TNF-alpha stimulated JNK phosphorylation via coupling to G alpha-q/11; the function involves dissociation of RIPK1 and TRADD from TNFR1. Mediates phosphorylation of nuclear factor NF-kappa-B RELA subunit at 'Ser-536'; the function involves IKBKB and is predominantly independent of G proteins. Involved in cellular migration. Involved in cytoskeletal rearrangement and chemotaxis through beta-arrestin-promoted scaffolds; the function is independent of G alpha-q/11 and involves promotion of cofilin dephosphoryltaion and actin filament severing. Induces redistribution of COPS5 from the plasma membrane to the cytosol and activation of the JNK cascade is mediated by COPS5. Involved in the recruitment of leukocytes to the sites of inflammation and is the major PAR receptor capable of modulating eosinophil function such as proinflammatory cytokine secretion, superoxide production and degranulation. During inflammation promotes dendritic cell maturation, trafficking to the lymph nodes and subsequent T-cell activation. Involved in antimicrobial response of innate immnune cells; activation enhances phagocytosis of Gram-positive and killing of Gram-negative bacteria. Acts synergistically with interferon-gamma in enhancing antiviral responses. Implicated in a number of acute and chronic inflammatory diseases such as of the joints, lungs, brain, gastrointestinal tract, periodontium, skin, and vascular systems, and in autoimmune disorders.<ref>PMID:10086357</ref> <ref>PMID:10725339</ref> <ref>PMID:11413129</ref> <ref>PMID:11441110</ref> <ref>PMID:11447194</ref> <ref>PMID:11714832</ref> <ref>PMID:12832443</ref> <ref>PMID:15155775</ref> <ref>PMID:16359518</ref> <ref>PMID:16410250</ref> <ref>PMID:16478888</ref> <ref>PMID:16714334</ref> <ref>PMID:17404307</ref> <ref>PMID:17500066</ref> <ref>PMID:18424071</ref> <ref>PMID:18453611</ref> <ref>PMID:18474671</ref> <ref>PMID:18622013</ref> <ref>PMID:19494303</ref> <ref>PMID:19781631</ref> <ref>PMID:19864598</ref> <ref>PMID:19865078</ref> <ref>PMID:20826780</ref> <ref>PMID:21501162</ref> [https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.[https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Escherichia coli]] |
| + | [[Category: Escherichia virus T4]] | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | + | [[Category: Aggeler B]] | |
| - | [[Category: Aggeler | + | [[Category: Brown DG]] |
| - | [[Category: Brown | + | [[Category: Brown G]] |
| - | [[Category: Brown | + | [[Category: Cheng RKY]] |
| - | [[Category: Cheng | + | [[Category: Cooke RM]] |
| - | [[Category: Cooke | + | [[Category: Dekker N]] |
| - | [[Category: Dekker | + | [[Category: Dore AS]] |
| - | [[Category: Dore | + | [[Category: Dumelin CE]] |
| - | [[Category: Dumelin | + | [[Category: Edman K]] |
| - | [[Category: Edman | + | [[Category: Fiez-Vandal C]] |
| - | [[Category: Fiez-Vandal | + | [[Category: Geschwindner S]] |
| - | [[Category: Geschwindner | + | [[Category: Grebner C]] |
| - | [[Category: Grebner | + | [[Category: Hermansson N-O]] |
| - | [[Category: Hermansson | + | [[Category: Jazayeri A]] |
| - | [[Category: Jazayeri | + | [[Category: Johansson P]] |
| - | [[Category: Johansson | + | [[Category: Leong L]] |
| - | [[Category: Leong | + | [[Category: Marshall FH]] |
| - | [[Category: Marshall | + | [[Category: Prihandoko R]] |
| - | [[Category: Prihandoko | + | [[Category: Rappas M]] |
| - | [[Category: Rappas | + | [[Category: Schlenker O]] |
| - | [[Category: Schlenker | + | [[Category: Snijder A]] |
| - | [[Category: Snijder | + | [[Category: Soutter H]] |
| - | [[Category: Soutter | + | [[Category: Sundstrom L]] |
| - | [[Category: Sundstrom | + | [[Category: Tehan B]] |
| - | [[Category: Tehan | + | [[Category: Thornton P]] |
| - | [[Category: Thornton | + | [[Category: Troast D]] |
| - | [[Category: Troast | + | [[Category: Wiggin G]] |
| - | [[Category: Wiggin | + | [[Category: Zhukov A]] |
| - | [[Category: Zhukov | + | |
| - | + | ||
| - | + | ||
Current revision
Crystal structure of a thermostabilised human protease-activated receptor-2 (PAR2) in complex with AZ8838 at 2.8 angstrom resolution
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Categories: Escherichia coli | Escherichia virus T4 | Homo sapiens | Large Structures | Aggeler B | Brown DG | Brown G | Cheng RKY | Cooke RM | Dekker N | Dore AS | Dumelin CE | Edman K | Fiez-Vandal C | Geschwindner S | Grebner C | Hermansson N-O | Jazayeri A | Johansson P | Leong L | Marshall FH | Prihandoko R | Rappas M | Schlenker O | Snijder A | Soutter H | Sundstrom L | Tehan B | Thornton P | Troast D | Wiggin G | Zhukov A
