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5nji

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Current revision (13:01, 15 November 2023) (edit) (undo)
 
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<StructureSection load='5nji' size='340' side='right'caption='[[5nji]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='5nji' size='340' side='right'caption='[[5nji]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5nji]] is a 1 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5cf7 5cf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NJI OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5NJI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5nji]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5cf7 5cf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NJI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NJI FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8Z2:~{S}-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethyl]+(~{E})-dodec-2-enethioate'>8Z2</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ooc|4ooc]], [[5l84|5l84]], [[5i0k|5i0k]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8Z2:~{S}-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethyl]+(~{E})-dodec-2-enethioate'>8Z2</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-ketoacyl-[acyl-carrier-protein]_synthase_I Beta-ketoacyl-[acyl-carrier-protein] synthase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.41 2.3.1.41] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5nji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nji OCA], [https://pdbe.org/5nji PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5nji RCSB], [https://www.ebi.ac.uk/pdbsum/5nji PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5nji ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5nji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nji OCA], [http://pdbe.org/5nji PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nji RCSB], [http://www.ebi.ac.uk/pdbsum/5nji PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nji ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PPSC_MYCBO PPSC_MYCBO]] Involved in the elongation of either C22-24 fatty acids or p-hydroxyphenylalkanoic acids by the addition of malonyl-CoA and methylmalonyl-CoA extender units to yield phthiocerol and phenolphthiocerol derivatives, respectively.<ref>PMID:9201977</ref>
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[https://www.uniprot.org/uniprot/PPSC_MYCTU PPSC_MYCTU] Involved in the elongation of either C22-24 fatty acids by the addition of malonyl-CoA and methylmalonyl-CoA extender units to yield phthiocerol derivatives.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Faille, A]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Gavalda, S]]
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[[Category: Faille A]]
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[[Category: Mourey, L]]
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[[Category: Gavalda S]]
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[[Category: Pedelacq, J D]]
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[[Category: Mourey L]]
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[[Category: Complex]]
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[[Category: Pedelacq JD]]
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[[Category: Dehydratase]]
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[[Category: Polyketide]]
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[[Category: Transferase]]
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[[Category: Tuberculosis]]
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Current revision

Structure of the dehydratase domain of PpsC from Mycobacterium tuberculosis in complex with C12:1-CoA

PDB ID 5nji

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