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5ody

From Proteopedia

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Current revision (16:46, 13 December 2023) (edit) (undo)
 
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<StructureSection load='5ody' size='340' side='right'caption='[[5ody]], [[Resolution|resolution]] 1.15&Aring;' scene=''>
<StructureSection load='5ody' size='340' side='right'caption='[[5ody]], [[Resolution|resolution]] 1.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ody]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ODY OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5ODY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ody]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ODY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ODY FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9SK:5,6-bis(fluoranyl)-3-[[(2~{R},3~{S},4~{S},5~{R},6~{S})-2-(hydroxymethyl)-6-[(2~{S},3~{R},4~{S},5~{R},6~{R})-6-(hydroxymethyl)-3,5-bis(oxidanyl)-4-[4-[3,4,5-tris(fluoranyl)phenyl]-1,2,3-triazol-1-yl]oxan-2-yl]sulfanyl-3,5-bis(oxidanyl)oxan-4-yl]oxymethyl]chromen-2-one'>9SK</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.149&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5ody FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ody OCA], [http://pdbe.org/5ody PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ody RCSB], [http://www.ebi.ac.uk/pdbsum/5ody PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ody ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9SK:5,6-bis(fluoranyl)-3-[[(2~{R},3~{S},4~{S},5~{R},6~{S})-2-(hydroxymethyl)-6-[(2~{S},3~{R},4~{S},5~{R},6~{R})-6-(hydroxymethyl)-3,5-bis(oxidanyl)-4-[4-[3,4,5-tris(fluoranyl)phenyl]-1,2,3-triazol-1-yl]oxan-2-yl]sulfanyl-3,5-bis(oxidanyl)oxan-4-yl]oxymethyl]chromen-2-one'>9SK</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ody FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ody OCA], [https://pdbe.org/5ody PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ody RCSB], [https://www.ebi.ac.uk/pdbsum/5ody PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ody ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/LEG3_HUMAN LEG3_HUMAN]] Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.<ref>PMID:15181153</ref> <ref>PMID:19594635</ref> <ref>PMID:19616076</ref>
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[https://www.uniprot.org/uniprot/LEG3_HUMAN LEG3_HUMAN] Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.<ref>PMID:15181153</ref> <ref>PMID:19594635</ref> <ref>PMID:19616076</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Kumar, R]]
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[[Category: Kumar R]]
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[[Category: Logan, D T]]
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[[Category: Logan DT]]
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[[Category: Nilsson, U J]]
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[[Category: Nilsson UJ]]
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[[Category: Peterson, K]]
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[[Category: Peterson K]]
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[[Category: Carbohydrate-binding protein]]
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[[Category: Galactose-specific lectin 3]]
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[[Category: Galactoside-binding protein]]
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[[Category: Galbp]]
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[[Category: Ige-6 binding protein]]
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[[Category: L-31]]
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[[Category: Laminin-binding protein]]
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[[Category: Lectin]]
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[[Category: Lectin l-29]]
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[[Category: Mac-2]]
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[[Category: Sugar binding protein]]
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Current revision

Galectin-3C in complex with dithiogalactoside derivative

PDB ID 5ody

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OCA

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