1cic

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[[Image:1cic.jpg|left|200px]]
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{{Seed}}
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[[Image:1cic.png|left|200px]]
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{{STRUCTURE_1cic| PDB=1cic | SCENE= }}
{{STRUCTURE_1cic| PDB=1cic | SCENE= }}
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'''IDIOTOPE-ANTI-IDIOTOPE FAB-FAB COMPLEX; D1.3-E225'''
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===IDIOTOPE-ANTI-IDIOTOPE FAB-FAB COMPLEX; D1.3-E225===
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==Overview==
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Serologically detected antigenic determinants unique to an antibody or group of antibodies are called idiotopes. The sum of idiotopes of an antibody constitute its idiotype. Idiotypes have been intensively studied following a hypothesis for the self-regulation of the immune system through a network of idiotype-anti-idiotype interactions. Furthermore, as antigen and anti-idiotypes can competitively bind to idiotype-positive, antigen-specific antibodies, anti-idiotypes may carry an 'internal image' of the external antigen. Here we describe the structure of the complex between the monoclonal anti-lysozyme FabD1.3 and the anti-idiotopic FabE225 at 2.5 A resolution. This complex defines a private idiotope consisting of 13 amino-acid residues, mainly from the complementarity-determining regions of D1.3. Seven of these residues make contacts with the antigen, indicating a significant overlap between idiotope and antigen-combining site. Idiotopic mimicry of the external antigen is not achieved at the molecular level in this example.
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The line below this paragraph, {{ABSTRACT_PUBMED_1700305}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 1700305 is the PubMed ID number.
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{{ABSTRACT_PUBMED_1700305}}
==About this Structure==
==About this Structure==
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[[Category: Idiotope]]
[[Category: Idiotope]]
[[Category: Immunoglobulin]]
[[Category: Immunoglobulin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:45:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:47:10 2008''

Revision as of 17:47, 30 June 2008

Image:1cic.png

Template:STRUCTURE 1cic

IDIOTOPE-ANTI-IDIOTOPE FAB-FAB COMPLEX; D1.3-E225

Template:ABSTRACT PUBMED 1700305

About this Structure

1CIC is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of an idiotope-anti-idiotope complex., Bentley GA, Boulot G, Riottot MM, Poljak RJ, Nature. 1990 Nov 15;348(6298):254-7. PMID:1700305

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